Abe Rokuo, Ogawa Kazuei, Maruyama Yukio, Nakamura Naoya, Abe Masafumi
Department of Internal Medicine, Fukushima-ken Taiyoh-no-kuni Hospital, Fukushima, Japan.
J Clin Exp Hematop. 2007 Apr;47(1):23-6. doi: 10.3960/jslrt.47.23.
We report an elderly patient with diffuse large B cell lymphoma harbouring Epstein-Barr virus that showed spontaneous regressions with subsequent relapses three times. The patient died of aspiration pneumonia without any anti-neoplastic treatment 5 years 10 months after the initial onset of lymph node swelling. In the literature, there are several reports of aggressive non-Hodgkin's lymphoma cases that showed spontaneous regressions without relapse till the last observation. Over half of the cases were the extra-nodal type. The tendency toward regression of swollen lymph nodes detected by clinicians occurs within 2 weeks after biopsy. If the remaining lymph nodes show a tendency to decrease in size after biopsy without any anti-tumor therapies, the patient may develop spontaneous regression.
我们报告了一例患有弥漫性大B细胞淋巴瘤且携带爱泼斯坦-巴尔病毒的老年患者，该患者出现了三次自发缓解及随后的复发。患者在淋巴结肿大首次出现后5年10个月，未接受任何抗肿瘤治疗，死于吸入性肺炎。在文献中，有几例侵袭性非霍奇金淋巴瘤病例报告显示自发缓解且直至最后一次观察时未复发。超过半数的病例为结外型。临床医生检测到的肿大淋巴结消退趋势出现在活检后2周内。如果活检后剩余淋巴结在未进行任何抗肿瘤治疗的情况下有缩小趋势，患者可能会出现自发缓解。
