Bshennaty Ahmad, Vogl Brennan J, Saleh Ghasaq, Sularz Agata, Alkhouli Mohamad, Hatoum Hoda
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA.
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
J Cardiovasc Transl Res. 2025 Feb 19. doi: 10.1007/s12265-025-10598-y.
Computational simulations are a powerful tool in the understanding, diagnosing, and treatment of cardiovascular diseases. Incomplete clinical data often limits computational assessment, which may lead to inaccuracies. This study aims to assess the sensitivity of left atrial flow dynamics to echocardiographic and computed tomography data. Models of the LA were reconstructed at the E-wave(Geometry 1)and end-diastolic(Geometry 2)phases from CT scans. CFD simulations were carried out using 3 different sets of BCs. BC2 and BC3 presented similar results that were significantly different from BC1. The effect from the choice of geometry was significant with BC2 and BC3 but minor with BC1. Differences in parameters across the simulated cases highlight the importance of using consistent BCs and geometries for CFD studies. Acquiring the pressure in the LA does not seem to be necessary for the accuracy of CFD simulations. Validation of all simulations indicates reliable patient-specific results.
计算模拟是理解、诊断和治疗心血管疾病的有力工具。不完整的临床数据常常限制计算评估，这可能导致不准确的结果。本研究旨在评估左心房血流动力学对超声心动图和计算机断层扫描数据的敏感性。从CT扫描的E波（几何形状1）和舒张末期（几何形状2）阶段重建左心房模型。使用3组不同的边界条件进行计算流体动力学模拟。边界条件2和边界条件3呈现出相似的结果，与边界条件1有显著差异。几何形状选择对边界条件2和边界条件3的影响显著，对边界条件1的影响较小。模拟案例中参数的差异凸显了在计算流体动力学研究中使用一致的边界条件和几何形状的重要性。获取左心房压力对于计算流体动力学模拟的准确性似乎并非必要。所有模拟的验证表明了针对患者的可靠结果。
