Lee Sun Young, Park Jeong Ho, Kim Yoonjic, Lee Jungah, Ro Young Sun, Song Kyoung Jun, Do Shin Sang
Public Healthcare Center, Seoul National University Hospital, Seoul, South Korea.
Department of Human Systems Medicine, Seoul National University College of Medicine, Seoul, South Korea.
BMC Cancer. 2025 Feb 19;25(1):301. doi: 10.1186/s12885-025-13717-9.
The importance of assessing out-of-hospital cardiac arrest (OHCA) risk in cancer patients is increasing as cancer incidence rises in aging populations.
This study aimed to investigate the association between newly diagnosed cancer and OHCA risk using a metropolitan cohort from South Korea.
A population-based retrospective cohort study was conducted, linking the nationwide OHCA registry with the National Health Information Database. The study included adults aged 40 years or older, residing in Seoul between 2015 and 2018, with no history of cancer or OHCA. The main exposure was cancer development. The primary outcome was the occurrence of OHCA with medical cause. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were calculated using a cause-specific hazard model considering death as a competing risk. Analyses stratified by age group and cancer type were also conducted.
During a follow-up period of up to 4 years for 5,450,438 individuals, 174,785 participants developed cancer. The incidence rates of OHCA per 100,000 person-years were 54.0 in non-cancer and 145.0 in cancer groups, respectively. The aHR (95% CI) for OHCA associated with cancer development was 3.18 (2.97-3.41). The aHR (95% CI) for OHCA was highest in the 40-49 years of age group (7.52 [5.52-10.25]), followed by 50-59 years old (6.66 [5.56-7.97]) compared to older age groups. By cancer type, pancreatic, lung, biliary tract, and liver cancer were associated with a significantly increased risk of OHCA.
We found an association between newly diagnosed cancer and the occurrence of OHCA. Our findings underscore the importance of tailored risk assessments and proactive care planning for patients with cancer.
随着老年人群中癌症发病率的上升，评估癌症患者院外心脏骤停（OHCA）风险的重要性日益增加。
本研究旨在利用韩国一个大城市队列调查新诊断癌症与OHCA风险之间的关联。
进行了一项基于人群的回顾性队列研究，将全国OHCA登记处与国家健康信息数据库相链接。该研究纳入了2015年至2018年居住在首尔、年龄在40岁及以上、无癌症或OHCA病史的成年人。主要暴露因素是癌症发生。主要结局是由医学原因导致的OHCA的发生。使用将死亡视为竞争风险的特定病因风险模型计算调整后的风险比（aHRs）和95%置信区间（CIs）。还按年龄组和癌症类型进行了分层分析。
在对5450438名个体长达4年的随访期内，174785名参与者患了癌症。非癌症组和癌症组每10万人年的OHCA发病率分别为54.0和145.0。与癌症发生相关的OHCA的aHR（95%CI）为3.18（2.97 - 3.41）。与年龄较大的组相比，OHCA的aHR（95%CI）在40 - 49岁年龄组中最高（7.52 [5.52 - 10.25]），其次是50 - 59岁（6.66 [5.56 - 7.97]）。按癌症类型划分，胰腺癌、肺癌、胆管癌和肝癌与OHCA风险显著增加相关。
我们发现新诊断癌症与OHCA的发生之间存在关联。我们的研究结果强调了针对癌症患者进行定制化风险评估和积极护理规划的重要性。
