缺铜小鼠淋巴细胞亚群的改变。
Alterations in lymphocyte subpopulations in copper-deficient mice.
作者信息
Lukasewycz O A, Prohaska J R, Meyer S G, Schmidtke J R, Hatfield S M, Marder P
出版信息
Infect Immun. 1985 Jun;48(3):644-7. doi: 10.1128/iai.48.3.644-647.1985.
Abstract
Analyses of cell surface determinants of splenocytes from copper-deficient C58 mice indicate alterations in lymphocyte subpopulation characteristics. Both the absolute number and the relative percentage of surface immunoglobulin-bearing (B) cells from copper-deficient mice were significantly greater than those from copper-supplemented controls. The relative percentage of Thy 1.2-positive (T) cells was decreased, and the decrease was most prominent within the Lyt 1-positive (helper) T-cell subset. The functional responsiveness of both B cells and T cells was decreased in copper deficiency.
摘要
对缺铜C58小鼠脾细胞的细胞表面决定簇分析表明淋巴细胞亚群特征发生改变。缺铜小鼠表面带有免疫球蛋白的（B）细胞的绝对数量和相对百分比均显著高于补铜对照组。Thy 1.2阳性（T）细胞的相对百分比降低，且在Lyt 1阳性（辅助）T细胞亚群中降低最为显著。缺铜时B细胞和T细胞的功能反应性均降低。
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