Clarke B, Ward D E, Honey M
Int J Cardiol. 1985 May;8(1):81-8. doi: 10.1016/0167-5273(85)90266-9.
A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immediate but gradual improvement followed withdrawal of amiodarone and treatment with prednisolone. Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.
一名患有窦房结疾病且植入了起搏器的患者，为控制室上性快速心律失常，接受了10个月的胺碘酮治疗（最大剂量1000毫克，维持剂量每日800毫克）。他出现了肺炎、胸腔和心包积液，以及以近端为主的运动神经病。停用胺碘酮并使用泼尼松龙治疗后，病情立即但逐渐好转。对该病例及之前报道病例的回顾表明，需要早期诊断胺碘酮肺炎，立即停用胺碘酮，并迅速且持续进行类固醇治疗以确保完全康复。
