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普通狨猴（绢毛猴）异氟烷最低肺泡浓度及丙泊酚有效血浆浓度的测定

Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (Callithrix jacchus).

作者信息

Muta Kanako, Koizumi Makoto, Miyabe-Nishiwaki Takako, Sotomaru Yusuke, Nobukiyo Asako, Ohta Hiroki, Okano Hirotaka James, Kamata Masatoshi, Nagakubo Dai, Nishimura Ryohei

机构信息

Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Division of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.

出版信息

J Med Primatol. 2025 Apr;54(2):e70006. doi: 10.1111/jmp.70006.

DOI:10.1111/jmp.70006
PMID:39973069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11840290/
Abstract

BACKGROUND

Common marmosets (Callithrix jacchus) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols have yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) and effective predicted plasma concentration of an injectable anesthetic (propofol) were measured for optimization of sedation and anesthetic protocols in marmosets.

METHODS

The minimum alveolar concentrations (MACs) for several stimulations (nociceptive stimulation, endotracheal intubation, and non-painful direct stimulation), MAC-noci, MAC-extb, and MAC-awake, respectively, were measured for isoflurane with the up-and-down method from four healthy marmosets. Predicted plasma concentrations 50 (Cp50s), which are equivalent to MACs of isoflurane, Cp50-noci, Cp50-extb, and Cp50-awake, respectively, were measured for propofol.

RESULTS

MAC-noci and MAC-extb of isoflurane in marmosets were 1.91% and 1.38%, respectively. MAC-awake was not determined owing to technical difficulties. Cp50-noci, Cp50-extb, and Cp50-awake were 9.45, 7.21, and 3.54 μg/mL, respectively.

CONCLUSIONS

The obtained results refined existing isoflurane and propofol for sedation and anesthesia in marmosets.

摘要

背景

普通狨猴（绢毛猴）已被广泛用作实验动物；然而，有限的镇静和麻醉方案尚未建立。在本研究中，测量了吸入麻醉剂（异氟烷）的最低肺泡浓度和注射用麻醉剂（丙泊酚）的有效预测血浆浓度，以优化狨猴的镇静和麻醉方案。

方法

采用上下法，从4只健康狨猴身上测量了异氟烷对几种刺激（伤害性刺激、气管插管和非疼痛直接刺激）的最低肺泡浓度（MACs），分别为MAC-伤害性、MAC-气管插管和MAC-清醒。测量了丙泊酚的预测血浆浓度50（Cp50s），分别相当于异氟烷的MACs，即Cp50-伤害性、Cp50-气管插管和Cp50-清醒。

结果

狨猴异氟烷的MAC-伤害性和MAC-气管插管分别为1.91%和1.38%。由于技术困难，未确定MAC-清醒。Cp50-伤害性、Cp50-气管插管和Cp50-清醒分别为9.45、7.21和3.54μg/mL。

结论

所得结果完善了现有的异氟烷和丙泊酚用于狨猴镇静和麻醉的方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20f/11840290/3193acc65526/JMP-54-e70006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20f/11840290/18f0e32d20cc/JMP-54-e70006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20f/11840290/3193acc65526/JMP-54-e70006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20f/11840290/18f0e32d20cc/JMP-54-e70006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20f/11840290/3193acc65526/JMP-54-e70006-g002.jpg

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