Di Padova F, Morandi E, Baldini L, Vallino F, Como G, Celega E
Boll Ist Sieroter Milan. 1979 Jan 31;57(6):765-73.
This paper evaluates the cellular immune system of 16 cadaver kidney transplant recipients more than three years after transplantation. The number and percent of active E rosette forming cells, of E rosette forming cells and of IgG and IgM bearing lymphocytes were determined; the blastogenic response of peripheral blood lymphocytes to PHA and PWM was studied in homologous and autologous serum. Significant alterations of the tests performed were found in patients who had undergone kidney transplant, suggesting a pathogenetic role of chronic immunosuppressive therapy but not excluding other possible factors.
本文评估了16例尸体肾移植受者在移植三年多后的细胞免疫系统。测定了活性E花环形成细胞、E花环形成细胞以及携带IgG和IgM的淋巴细胞的数量和百分比;在同源和自体血清中研究了外周血淋巴细胞对PHA和PWM的增殖反应。在接受肾移植的患者中发现所进行检测有显著改变,提示慢性免疫抑制治疗的致病作用,但不排除其他可能因素。