Birkeland S A
J Clin Lab Immunol. 1981 Jan;5(1):47-51.
The eventual dependency of a series of immune parameters on age has been studied in a material of 288 normal persons, divided into 2 sexes and with 16 persons in each 5-year age interval between 5 and 95 years, using a cryobiological freezing and storage system for lymphocytes with subsequent testing in large series. Lymphocyte transformation responses were studied after stimulation with a series of mitogens and specific antigens (PHA, PWM, PPD, Con A, SA, EC, CA and SK/SD), as well as with allogene cells in mixed lymphocyte culture. Values were found to decrease with increasing age. No age-dependency could be demonstrated for T and B lymphocytes using rosette formation tests. There was no difference between the two sexes. Thus, increasing age does not change the distribution between T and B lymphocytes, but does lead to a decrease in the function of the cell-mediated response.
在288名正常人的样本中研究了一系列免疫参数最终对年龄的依赖性。这些样本分为两性，在5至95岁之间，每5年年龄间隔中有16人，使用淋巴细胞的低温生物学冷冻和储存系统，随后进行大量测试。在用一系列促细胞分裂剂和特异性抗原（PHA、PWM、PPD、Con A、SA、EC、CA和SK/SD）刺激后，以及在混合淋巴细胞培养中用同种异体细胞刺激后，研究淋巴细胞转化反应。发现随着年龄的增长数值会下降。使用玫瑰花结形成试验未证明T和B淋巴细胞存在年龄依赖性。两性之间没有差异。因此，年龄增长不会改变T和B淋巴细胞之间的分布，但会导致细胞介导反应的功能下降。
