SARS-CoV-2感染后高危个体健康相关生活质量的纵向描述：一项荷兰多中心观察性队列研究。
A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort Study.
作者信息
Vergouwe Magda, Birnie Emma, van Veelen Sarah, Biemond Jason J, Appelman Brent, Peters-Sengers Hessel, de Bree Godelieve J, Popping Stephanie, Wiersinga W Joost
机构信息
Center for Infection and Molecular Medicine, Amsterdam University Medical Center, Location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, the Netherlands.
出版信息
Open Forum Infect Dis. 2025 Jan 30;12(2):ofaf055. doi: 10.1093/ofid/ofaf055. eCollection 2025 Feb.
BACKGROUND
Health-related quality of life (HRQoL) data post-COVID-19 in patients with medical conditions associated with severe disease are lacking. Here, we assess the longitudinal impact of COVID-19 on HRQoL and employment status in individuals at high risk.
METHODS
This multicenter prospective cohort study included individuals at high risk for severe disease who were hospitalized or not-hospitalized with SARS-CoV-2 infection (September 2021-February 2024). Questionnaires about HRQoL and employment status were collected at 3, 6, and 12 months post-COVID-19 and retrospectively recalled and reported for pre-COVID-19. With a mixed effects model, we assessed the course of and risk factors for changes in HRQoL utility score.
RESULTS
Among 332 individuals (median age, 59.8 years [IQR, 48.8-67.1]; 50.6% female), 184 (55.4%) were hospitalized for COVID-19 (intensive care unit admission, 12.0%). High-risk factors included solid organ transplantation (19.6%), hematologic malignancies (28.0%), and immunosuppressive medication use (56.6%). The median HRQoL utility score declined from 0.85 (IQR, 0.74-1.00) pre-COVID-19 to 0.81 (0.70-0.92) 12 months post-COVID-19 ( = .007). Solid organ transplant recipients and patients requiring oxygen therapy were at risk for an HRQoL decrease over 1 year. At 12 months, 45.3% of all employed responders had reported sick leave related to COVID-19 symptoms. Employed patients who reported sick leave had lower median HRQoL utility scores (0.81 [IQR, 0.72-0.91]) than those who did not (0.89 [0.86-1.00], = .002).
CONCLUSIONS
Solid organ transplant recipients and individuals requiring oxygen therapy experience a substantial HRQoL decline over 12 months post-COVID-19. Moreover, almost half of employed participants reported COVID-19-related sick leave, correlating with lower HRQoL. This highlights the continuous burden of COVID-19 for this vulnerable population and supports the implementation of preventive approaches.
背景
缺乏关于患有与重症相关疾病的患者在感染新冠病毒后与健康相关的生活质量（HRQoL）数据。在此，我们评估新冠病毒对高危个体的HRQoL和就业状况的长期影响。
方法
这项多中心前瞻性队列研究纳入了因感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）而住院或未住院的重症高危个体（2021年9月至2024年2月）。在感染新冠病毒后的3个月、6个月和12个月收集有关HRQoL和就业状况的问卷，并对新冠病毒感染前的情况进行回顾性回忆和报告。我们使用混合效应模型评估HRQoL效用评分变化的过程和危险因素。
结果
在332名个体中（中位年龄59.8岁[四分位间距，48.8 - 67.1]；50.6%为女性），184人（55.4%）因新冠病毒感染住院（入住重症监护病房的比例为12.0%）。高危因素包括实体器官移植（19.6%）、血液系统恶性肿瘤（28.0%）和使用免疫抑制药物（56.6%）。HRQoL效用评分中位数从新冠病毒感染前的0.85（四分位间距，0.74 - 1.00）降至感染后12个月的0.81（0.70 - 0.92）（P = 0.007）。实体器官移植受者和需要吸氧治疗的患者在1年内有HRQoL下降的风险。在12个月时，所有有工作的应答者中有45.3%报告因新冠病毒症状请过病假。报告请过病假的有工作患者的HRQoL效用评分中位数（0.81[四分位间距，0.72 - 0.91]）低于未请过病假的患者（0.89[0.86 - 1.00]，P = 0.002）。
结论
实体器官移植受者和需要吸氧治疗的个体在感染新冠病毒后的12个月内HRQoL大幅下降。此外，近一半有工作的参与者报告因新冠病毒请过病假，这与较低的HRQoL相关。这凸显了新冠病毒对这一脆弱人群的持续负担，并支持实施预防措施。
Zotero 插件