Xue Yang, Shi Wei, Lun Bing, Kan Meilin, Jia Mengling, Wu Yuelin, Yang Li
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhengzhou Key Laboratory of Endometrial Disease Prevention and Treatment, Zhengzhou, China.
Front Oncol. 2025 Feb 5;15:1512616. doi: 10.3389/fonc.2025.1512616. eCollection 2025.
Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models. The use of spontaneous and chemically-induced models has decreased, with transgenic mouse and xenograft models becoming the most widely used. These models better simulate tumor molecular mechanisms and treatments, with the organoid-based patient-derived xenograft model (O-PDX) showing great promise in drug screening and personalized therapy. The application of humanized models remains limited due to technical challenges and high costs. In this review, we highlight the strengths and limitations of each model to guide researchers in their selection.
子宫内膜癌（EC）是发达国家最常见的妇科恶性肿瘤，近年来发病率呈上升趋势。实验动物模型对于研究发病机制、推进诊断方法和开发新疗法至关重要。我们综述了五种主要的子宫内膜癌动物模型。自发模型和化学诱导模型的使用有所减少，转基因小鼠模型和异种移植模型成为使用最广泛的模型。这些模型能更好地模拟肿瘤分子机制和治疗方法，基于类器官的患者来源异种移植模型（O-PDX）在药物筛选和个性化治疗方面显示出巨大潜力。由于技术挑战和成本高昂，人源化模型的应用仍然有限。在本综述中，我们强调了每种模型的优缺点，以指导研究人员进行选择。
