Kim Jee Wook, Byun Min Soo, Yi Dahyun, Jung Joon Hyung, Kong Nayeong, Chang Yoon Young, Jung Gijung, Ahn Hyejin, Lee Jun-Young, Kang Koung Mi, Sohn Chul-Ho, Lee Yun-Sang, Kim Yu Kyeong, Lee Dong Young
Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Gyeonggi, Republic of Korea.
Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Gangwon, Republic of Korea.
J Alzheimers Dis. 2025 Mar;104(1):138-149. doi: 10.1177/13872877251314176. Epub 2025 Feb 21.
BackgroundLittle information is yet available for the association between daily water intake, a modifiable lifestyle factor, and Alzheimer's disease (AD) pathology and cerebrovascular injury in the living human brain.ObjectiveOur aim was to explore the correlation between daily fluid intake and in vivo AD pathologies (i.e., amyloid-β (Aβ) and tau) and cerebrovascular injury.Methods287 cognitively normal (CN) older adults completed extensive clinical assessments, daily fluid intake evaluations, and multimodal brain imaging at both the initial baseline and the subsequent 2-year follow-up.ResultsLow daily fluid intake was significantly associated with a higher level or a more rapid increase of Aβ deposition, especially in apolipoprotein E4 negative individuals. Meanwhile, low daily fluid intake was cross-sectionally related with cerebrovascular injury.ConclusionsOur findings suggest that high daily fluid intake is associated with decreased brain amyloid deposition, indicating that sufficient daily fluid intake may be helpful for prevention of AD.
关于日常饮水量这一可改变的生活方式因素与活体人类大脑中阿尔茨海默病（AD）病理及脑血管损伤之间的关联，目前可用信息较少。
我们的目的是探讨每日液体摄入量与体内AD病理（即淀粉样β蛋白（Aβ）和tau蛋白）及脑血管损伤之间的相关性。
287名认知正常（CN）的老年人在初始基线和随后的2年随访时均完成了广泛的临床评估、每日液体摄入量评估以及多模态脑成像检查。
每日液体摄入量低与Aβ沉积水平较高或增加较快显著相关，尤其是在载脂蛋白E4阴性个体中。同时，每日液体摄入量低与脑血管损伤存在横断面关联。
我们的研究结果表明，每日液体摄入量高与脑淀粉样蛋白沉积减少有关，这表明每日摄入足够的液体可能有助于预防AD。
