Saez-Calveras Nil, Ishii Makoto
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Alzheimers Dis. 2025 Jun;105(3):759-761. doi: 10.1177/13872877251331590. Epub 2025 Apr 21.
Despite older adults being more susceptible to dehydration, the relation between hydration and Alzheimer's disease and related dementias (ADRD) remains largely unexplored. A recent study by Jee Wook Kim and colleagues examined the association between daily fluid intake and ADRD neuroimaging biomarkers in 287 cognitively normal older adults. They found that lower daily fluid intake was associated with greater brain Aβ deposition and cerebrovascular injury. Here, we discuss the strengths and limitations of this study. We further highlight the potential for reverse causality and how hydration may play a role in the clinic and future ADRD research studies.
尽管老年人更容易脱水，但水合作用与阿尔茨海默病及相关痴呆症（ADRD）之间的关系在很大程度上仍未得到探索。Jee Wook Kim及其同事最近进行的一项研究，调查了287名认知正常的老年人的每日液体摄入量与ADRD神经影像生物标志物之间的关联。他们发现，每日液体摄入量较低与大脑中更大程度的β淀粉样蛋白沉积和脑血管损伤有关。在此，我们讨论这项研究的优点和局限性。我们进一步强调了反向因果关系的可能性，以及水合作用在临床和未来ADRD研究中可能发挥的作用。
