流感二重感染所致脓毒性休克后心肌钙化的快速发作：一例报告
Rapid onset of myocardial calcification following septic shock due to influenza superinfection: a case report.
作者信息
Gobé Thibaut, Werquin Adrien, Polge Nicolas, Cholley Bernard
机构信息
Department of Anesthesiology and Intensive Care Medicine, Hôpital Européen Georges Pompidou, AP-HP, 20 Rue Leblanc 75015, Paris, France.
Université Paris Cité, Inserm UMR_S 1140, F-75006 Paris, France.
出版信息
Eur Heart J Case Rep. 2025 Feb 20;9(2):ytae609. doi: 10.1093/ehjcr/ytae609. eCollection 2025 Feb.
BACKGROUND
Myocardial calcification is an unusual complication of septic cardiomyopathy. Dystrophic calcification may occur after damage to myocardial tissue, but its occurrence is rare.
CASE SUMMARY
A 42-year-old pregnant woman with no past medical history was admitted in intensive care for respiratory distress caused by bacterial superinfection of influenza. Subepicardial calcification of the left ventricle appeared on a computed tomography at Day 8. Calcification worsened quickly, but we observed a paradoxical improvement in left ventricle function, as assessed by left ventricular ejection fraction and global longitudinal strain using echocardiography with speckle tracking.
DISCUSSION
The pathophysiology of myocardial calcification is not fully understood, but prolonged haemodynamic failure, profound acidosis, high vasopressor doses, and acute respiratory distress syndrome were previously associated with septic-related myocardial calcification.
背景
心肌钙化是脓毒性心肌病一种罕见的并发症。营养不良性钙化可能在心肌组织受损后发生，但其发生率很低。
病例摘要
一名42岁无既往病史的孕妇因流感细菌二重感染导致呼吸窘迫入住重症监护病房。第8天的计算机断层扫描显示左心室心外膜下钙化。钙化迅速加重，但通过斑点追踪超声心动图测量左心室射血分数和整体纵向应变评估发现，左心室功能出现了矛盾性改善。
讨论
心肌钙化的病理生理学尚未完全明确，但既往认为长时间血流动力学衰竭、严重酸中毒、高剂量血管升压药以及急性呼吸窘迫综合征与脓毒症相关的心肌钙化有关。
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