Ahmed Talha, Inayat Faisal, Haq Muhammad, Ahmed Taha
University of Maryland Medical Center - Midtown Campus, Baltimore, Maryland, USA.
Allama Iqbal Medical College, Lahore, Pakistan.
BMJ Case Rep. 2019 Jan 10;12(1):bcr-2018-228054. doi: 10.1136/bcr-2018-228054.
Myocardial calcification is a rare and life-threatening condition. It has been associated with a myriad of causes, including ischaemic heart disease, cardiac surgery, rheumatic fever, and myocarditis. However, this entity is less well recognised in the setting of toxic shock syndrome. Published medical literature is scarce with regard to the pathogenesis and clinical implications of this potential association. We chronicle here the case of a patient with myocardial calcification secondary to toxic shock syndrome from our clinical experience. Furthermore, a systematic literature search of the medical databases PubMed and Google Scholar was conducted. A total of 17 cases fulfilled the inclusion criteria. The data on patients' characteristics, epidemiology, clinical features, comorbid conditions, diagnosis, clinical course and outcome were collected and analysed. The present review outlines our current understanding of the epidemiology of and risk factors for sepsis-related myocardial calcification, the pathophysiology of this condition and currently available approaches to diagnosis.
心肌钙化是一种罕见且危及生命的病症。它与多种病因相关，包括缺血性心脏病、心脏手术、风湿热和心肌炎。然而，在中毒性休克综合征的背景下，这种情况的认知度较低。关于这种潜在关联的发病机制和临床意义，已发表的医学文献很少。我们在此根据临床经验记录了一例因中毒性休克综合征继发心肌钙化的患者病例。此外，我们对医学数据库PubMed和谷歌学术进行了系统的文献检索。共有17例符合纳入标准。收集并分析了患者的特征、流行病学、临床特征、合并症、诊断、临床病程和结局等数据。本综述概述了我们目前对脓毒症相关心肌钙化的流行病学和危险因素、该病症的病理生理学以及目前可用的诊断方法的理解。
