有氧运动训练通过激活海马体中的蛋白激酶A-环磷腺苷效应元件结合蛋白-脑源性神经营养因子信号通路，改善低氧暴露大鼠的学习和记忆能力。
Aerobic exercise training improves learning and memory performance in hypoxic-exposed rats by activating the hippocampal PKA-CREB-BDNF signaling pathway.
作者信息
Luo Shichen, Shi Lei, Liu Tong, Jin Qiguan
机构信息
College of Physical Education, Yangzhou University, Yangzhou, 225127, Jiangsu, China.
Nanjing Yincheng Primary School, Nanjing Yincheng Primary School Education Group, Nanjing, 210036, Jiangsu, China.
出版信息
BMC Neurosci. 2025 Feb 21;26(1):13. doi: 10.1186/s12868-025-00935-x.
BACKGROUND
This study aims to investigate the effects of aerobic exercise training on learning and memory (L&M) performance in rats exposed to altitude hypoxia and its relationship with hippocampal plasticity and the PKA-CREB-BDNF signaling pathway.
METHODS
Male Sprague-Dawley rats were exposed to 14.2% hypoxia with or without 60 min of non-weight-bearing swimming training for 8 weeks. The L&M performance was evaluated using the Morris water maze, and the mRNA expression of PSD95, SYP, PKA, CREB, CBP, and BDNF in the hippocampus was detected.
RESULTS
Chronic hypoxia exposure significantly impaired L&M performance and reduced the mRNA expression of hippocampal PSD95, SYP, PKA, CREB, CBP, and BDNF. Aerobic exercise training effectively reversed these changes by enhancing hippocampal synaptic plasticity through the activation of the PKA-CREB-BDNF signaling pathway.
CONCLUSION
Aerobic exercise training can alleviate the decline in L&M performance caused by altitude hypoxia exposure, possibly through the activation of the hippocampal PKA-CREB-BDNF signaling pathway.
背景
本研究旨在探讨有氧运动训练对暴露于高原低氧环境下大鼠学习记忆（L&M）能力的影响，及其与海马可塑性和PKA-CREB-BDNF信号通路的关系。
方法
将雄性Sprague-Dawley大鼠暴露于14.2%的低氧环境中，进行或不进行60分钟的无负重游泳训练，持续8周。使用Morris水迷宫评估L&M能力，并检测海马中PSD95、SYP、PKA、CREB、CBP和BDNF的mRNA表达。
结果
长期暴露于低氧环境显著损害L&M能力，并降低海马PSD95、SYP、PKA、CREB、CBP和BDNF的mRNA表达。有氧运动训练通过激活PKA-CREB-BDNF信号通路增强海马突触可塑性，有效逆转了这些变化。
结论
有氧运动训练可能通过激活海马PKA-CREB-BDNF信号通路，缓解高原低氧暴露引起的L&M能力下降。
Zotero 插件