Shabil Muhammed, Gaidhane Abhay M, Vadia Nasir, Menon Soumya V, Chennakesavulu Kattela, Panigrahi Rajashree, Bushi Ganesh, Jena Diptismita, Rani Anju, Sah Sanjit, Singh Mahendra, Satapathy Prakasini, Goh Khang Wen, Razaqi Nosaibah
University Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia.
BMC Neurol. 2025 Feb 21;25(1):71. doi: 10.1186/s12883-025-04083-x.
Hydrocarbon exposure, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), is increasingly linked to vascular dysfunction and stroke, a leading cause of morbidity and mortality globally. Common in occupational and environmental contexts, hydrocarbons induce oxidative stress, systemic inflammation, and endothelial dysfunction, disrupting vascular health. This systematic review examines the association between hydrocarbon exposure and stroke, emphasizing specific metabolites and their cerebrovascular effects.
A comprehensive search across PubMed, Embase, and Web of Science was conducted through December 10 2024, identifying observational studies exploring hydrocarbon exposure and stroke risk. Studies meeting predefined inclusion criteria, excluding those with major methodological flaws, were synthesized narratively. Variations in hydrocarbon types, population demographics, and stroke outcomes were considered.
Six studies, including five cross-sectional and one retrospective cohort, with sample sizes ranging from 5,537 to 283,666 participants, demonstrated significant associations between hydrocarbon exposure and stroke risk. Key findings revealed strong associations for metabolites like 1-hydroxynaphthalene (OR: 1.89; 95% CI: 1.62-2.20) and 2-hydroxyfluorene (OR: 1.94; 95% CI: 1.66-2.26). However, variability in findings was noted, attributed to differences in study design, exposure levels, and populations studied.
This review highlights a complex relationship between hydrocarbon exposure and stroke risk, with some studies indicating significant associations and others reporting inconsistencies. Standardized, large-scale research is essential to clarify this relationship, identify high-risk populations, and guide public health strategies to mitigate exposure and prevent stroke.
Not applicable.
碳氢化合物暴露，包括多环芳烃（PAHs）和挥发性有机化合物（VOCs），与血管功能障碍和中风的关联日益密切，中风是全球发病和死亡的主要原因。碳氢化合物在职业和环境中很常见，会引发氧化应激、全身炎症和内皮功能障碍，从而破坏血管健康。本系统综述探讨碳氢化合物暴露与中风之间的关联，重点关注特定代谢物及其对脑血管的影响。
截至2024年12月10日，在PubMed、Embase和Web of Science上进行了全面检索，以识别探索碳氢化合物暴露与中风风险的观察性研究。对符合预定义纳入标准的研究（排除那些存在重大方法学缺陷的研究）进行叙述性综合分析。考虑了碳氢化合物类型、人群人口统计学特征和中风结局的差异。
六项研究，包括五项横断面研究和一项回顾性队列研究，样本量从5537名到283666名参与者不等，表明碳氢化合物暴露与中风风险之间存在显著关联。主要发现显示，1-羟基萘（OR：1.89；95%CI：1.62-2.20）和2-羟基芴（OR：1.94；95%CI：1.66-2.26）等代谢物之间存在强关联。然而，研究结果存在差异，这归因于研究设计、暴露水平和所研究人群的不同。
本综述强调了碳氢化合物暴露与中风风险之间的复杂关系，一些研究表明存在显著关联，而另一些研究则报告了不一致的结果。标准化的大规模研究对于阐明这种关系、识别高危人群以及指导公共卫生策略以减少暴露和预防中风至关重要。
不适用。
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