甘油三酯-葡萄糖相关指标与胰腺癌发病风险的关联：英国生物银行的一项大规模前瞻性队列研究

Associations between triglyceride-glucose related indices and the risk of incident pancreatic cancer: a large-scale prospective cohort study in the UK Biobank.

作者信息

Wu Zelong, Yang Jiayu, Ma Zuyi, Chen Yubin, Han Mingqian, Wu Qianlong, Zhang Chuanzhao, Huang Shanzhou, Hou Baohua, Zhou Qi

机构信息

Department of Hepatological Surgery, Maoming People's Hospital, Maoming, 525000, China.

Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences, Southern Medical University, No.106, Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, China.

出版信息

BMC Cancer. 2025 Feb 21;25(1):327. doi: 10.1186/s12885-025-13718-8.

DOI:10.1186/s12885-025-13718-8

PMID:39984911

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11846352/

Abstract

BACKGROUND

Triglyceride-Glucose (TyG) index, a novel surrogate marker for insulin resistance, has been linked to the risk of various cancers, such as breast and colorectal cancers. However, the relationship between the TyG index and its related indices with the risk of pancreatic cancer(PC) remains unclear.

METHODS

This large-scale, prospective cohort study utilized data from the UK Biobank, involving 428,152 participants who were free of PC at baseline. The primary outcome was incident PC. To evaluate the relationships between TyG-related indices and PC onset, covariate-adjusted Cox proportional hazards regression models and restricted cubic spline (RCS) analyses were employed. Additionally, we explored the relationships between TyG-related indices and incident PC within subgroups defined by age, gender, diabetes, hypertension, pancreatitis history, smoking status, and drinking status. Sensitivity analyses were conducted to confirm the robustness of our findings.

RESULTS

Over an average follow-up period of 13.8 years, a total of 1,759 PC cases occurred. The risk of developing PC increased with higher levels of TyG-related indices. RCS curves illustrated a linear positive relationship between TyG-related indices and incident PC. Subgroup analyses indicated that the relationships between the TyG index, TyG-waist circumference, and TyG-waist-to-hip ratio and PC risk were more pronounced in participants without hypertension, without pancreatitis history, and those with drinking history (P for interaction < 0.05). Sensitivity analyses further validated the robustness of these findings.

CONCLUSIONS

TyG-related indices were independently related with a higher risk of incident PC, highlighting the importance of incorporating these indices into PC risk assessment tools and provides strong support for constructing a more comprehensive PC risk assessment framework.

摘要

背景

甘油三酯-葡萄糖（TyG）指数是一种新的胰岛素抵抗替代指标，已被证明与多种癌症的风险相关，如乳腺癌和结直肠癌。然而，TyG指数及其相关指标与胰腺癌（PC）风险之间的关系仍不明确。

方法

这项大规模前瞻性队列研究使用了英国生物银行的数据，涉及428,152名基线时无PC的参与者。主要结局是新发PC。为了评估TyG相关指标与PC发病之间的关系，采用了协变量调整的Cox比例风险回归模型和受限立方样条（RCS）分析。此外，我们还探讨了TyG相关指标与按年龄、性别、糖尿病、高血压、胰腺炎病史、吸烟状况和饮酒状况定义的亚组内新发PC之间的关系。进行敏感性分析以确认我们研究结果的稳健性。

结果

在平均13.8年的随访期内，共发生了1,759例PC病例。PC发病风险随着TyG相关指标水平的升高而增加。RCS曲线显示TyG相关指标与新发PC之间呈线性正相关。亚组分析表明，TyG指数、TyG-腰围和TyG腰臀比与PC风险之间的关系在无高血压、无胰腺炎病史和有饮酒史的参与者中更为明显（交互作用P<0.05）。敏感性分析进一步验证了这些结果的稳健性。