Li Hongyu, Jiang Guoheng, Yu Wenqian, Luo Jing, Li Shiyi, Xie Linjun, Bai Xuan, Xu Yiting, Jiang Yi, He Menglin, Zhou Jin, Wang Xin
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Department of Anorectal Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
J Gastroenterol Hepatol. 2025 Feb;40(2):404-412. doi: 10.1111/jgh.16828. Epub 2024 Dec 7.
Gallstone disease (GSD) is one of the widespread gastrointestinal conditions. Triglyceride-glucose (TyG) index, a convenient surrogate for insulin resistance, may help identify and prevent gallstones. The present study aims to conduct a longitudinal study to evaluate the association between TyG index and the risk of GSD using the UK Biobank cohort.
A total of 395 391 participants in the UK Biobank (median follow-up of 12.52 years) were included. The association between TyG index and the risk of GSD was assessed through Cox models and the restricted cubic spline model, expressed by hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup analysis was employed concerning age, gender, and body mass index (BMI) and also analyzed the mediating role of BMI in the effect of TyG index on incident GSD. Sensitivity analyses were further performed using a competing risks model and excluding participants who developed GSD in the first year of follow-up to test the stability of the results.
The risk of developing GSD increased in the Quartiles 2, 3, and 4 compared with Quartile 1 of TyG index (adjusted HR [aHR] 1.570 [95%CI 1.303-1.893], 1.577 [1.295-1.920], 1.489 [1.181-1.878], P < 0.001 across quartiles of TyG index). The aHR for every unit and SD increment in TyG index were 1.282 [1.100-1.494], 1.151 [1.055-1.256]. The results were consistent when participants who developed GSD in the first year of follow-up were excluded. The restricted cubic spline regression also showed an increased risk of GSD with increasing TyG index.
Increased TyG index is associated with an elevated risk of GSD. The TyG index might be an important indicator for identifying people at high risk of GSD.
胆结石病（GSD）是一种常见的胃肠道疾病。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的便捷替代指标，可能有助于识别和预防胆结石。本研究旨在进行一项纵向研究，利用英国生物银行队列评估TyG指数与GSD风险之间的关联。
纳入英国生物银行的395391名参与者（中位随访时间为12.52年）。通过Cox模型和受限立方样条模型评估TyG指数与GSD风险之间的关联，以风险比（HRs）和95%置信区间（CIs）表示。对年龄、性别和体重指数（BMI）进行亚组分析，并分析BMI在TyG指数对新发GSD影响中的中介作用。使用竞争风险模型并排除随访第一年发生GSD的参与者进行敏感性分析，以检验结果的稳定性。
与TyG指数第一四分位数相比，第二、第三和第四四分位数发生GSD的风险增加（调整后HR [aHR]分别为1.570 [95%CI 1.303 - 1.893]、1.577 [1.295 - 1.920]、1.489 [1.181 - 1.878]，TyG指数各四分位数间P < 0.001）。TyG指数每增加一个单位和一个标准差的aHR分别为1.282 [1.100 - 1.494]、1.151 [1.055 -
