Helander Anders, Sparring Fredrik
Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Pharmacology and Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden.
Drug Test Anal. 2025 Sep;17(9):1694-1700. doi: 10.1002/dta.3863. Epub 2025 Feb 22.
Recent data indicate that the use of controlled substances is increasing in working life, which can negatively affect work environment, performance, and safety. Many employers have an alcohol and drug policy that describes routines for preventive measures and early detection of illicit drug use. This often includes drug tests that provide objective information about recent use, and can be done routinely, randomly, and on suspicion. For some substances, however, a positive drug test may also result from prescription as medicine. Controlled substances that are abused and prescribed include amphetamines (ADHD medication), benzodiazepines and opiates. In a 2023 study of 23,900 urine and oral fluid drug test results from Swedish workplaces, 4.6% tested positive for one or more controlled substances. Most samples were collected in connection with random testing (40%) and new employment (36%), whereas the highest proportions of drug-positive samples were observed in cases related to accidents or incidents, or on suspicion of drug use. The highest percentage of positive random drug tests was recorded in the construction sector. The most common substances were cannabis (> 40% of cases), amphetamine (> 20%), and cocaine and benzodiazepines (> 10% each). However, many samples containing opiates (71% of cases), amphetamine (63%) and benzodiazepines (44%) were verified by a specialist trained Medical Review Officer (MRO) to be due to medical prescription, while those containing cannabis or cocaine were almost entirely due to illicit drug use. Considering the potentially negative consequences of a positive drug test in working life, an MRO should verify the results before they become final.
近期数据表明,工作场所中管制药品的使用呈上升趋势,这可能会对工作环境、工作表现和安全产生负面影响。许多雇主都制定了酒精和毒品政策,其中描述了预防措施和非法药物使用早期检测的流程。这通常包括药物检测,其能提供有关近期用药情况的客观信息,检测可定期、随机进行,也可基于怀疑进行。然而,对于某些物质,药物检测呈阳性也可能是因为按处方用药。被滥用和开具处方的管制药品包括安非他明(用于治疗注意力缺陷多动障碍的药物)、苯二氮䓬类药物和阿片类药物。在一项针对瑞典工作场所23900份尿液和口腔液药物检测结果的2023年研究中,4.6%的检测结果显示一种或多种管制药品呈阳性。大多数样本是在随机检测(40%)和新员工入职(36%)时采集的,而药物检测呈阳性的样本比例最高的情况出现在与事故或事件相关的案例中,或是在怀疑有药物使用的情况下。随机药物检测阳性率最高的行业是建筑业。最常见的物质是大麻(超过40%的案例)、安非他明(超过20%)、可卡因和苯二氮䓬类药物(各超过10%)。然而,许多含有阿片类药物(71%的案例)、安非他明(63%)和苯二氮䓬类药物(44%)的样本经专业培训的医学审核官(MRO)核实是因医疗处方所致,而含有大麻或可卡因的样本几乎完全是由于非法药物使用。考虑到工作场所药物检测呈阳性可能带来的潜在负面后果,医学审核官应在检测结果最终确定前进行核实。