Rodrigues Bianca Andrade, Silva Josiane do Nascimento, Kawamoto Elisa Mitiko
Laboratory of Molecular and Functional Neurobiology, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Cerebellum. 2025 Feb 22;24(2):52. doi: 10.1007/s12311-025-01806-1.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication and restricted and repetitive patterns of behavior. In addition, individuals diagnosed with ASD may also present cognitive impairments. The neurobiological mechanisms possibly associated with the cause of ASD have not yet been fully elucidated. Studies suggest that brain alterations, especially in the cerebellum, play a fundamental role in the etiology of ASD. This brain region, traditionally associated with motor control, has been implicated in several cognitive and emotional processes, many of which are impaired in autistic individuals. This mini-review examines the evidence on cerebellar abnormalities associated with ASD, discussing their implications for the understanding and treatment of the disorder.
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是社交沟通困难以及行为模式受限和重复。此外，被诊断患有ASD的个体也可能存在认知障碍。与ASD病因可能相关的神经生物学机制尚未完全阐明。研究表明，大脑改变，尤其是小脑的改变，在ASD的病因学中起着重要作用。这个传统上与运动控制相关的脑区，已被牵涉到多个认知和情感过程中，其中许多过程在自闭症个体中受损。这篇小型综述考察了与ASD相关的小脑异常的证据，讨论了它们对该疾病理解和治疗的意义。
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