Tang Yali, Zhang Yizhu, Chen Chen, Cao Ying, Wang Qiaona, Tang Chuanfeng
Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
J Cent Nerv Syst Dis. 2025 Feb 21;17:11795735251322450. doi: 10.1177/11795735251322450. eCollection 2025.
Under normal physiological conditions, gut microbiota and host mutually coexist. They play key roles in maintaining intestinal barrier integrity, absorption, and metabolism, as well as promoting the development of the central nervous system (CNS) and emotional regulation. The dysregulation of gut microbiota homeostasis has attracted significant research interest, specifically in its impact on neurological and psychiatric disorders. Recent studies have highlighted the important role of the gut- brain axis in conditions including Alzheimer's Disease (AD), Parkinson's Disease (PD), and depression. This review aims to elucidate the regulatory mechanisms by which gut microbiota affect the progression of CNS disorders via the gut-brain axis. Additionally, we discuss the current research landscape, identify gaps, and propose future directions for microbial interventions against these diseases. Finally, we provide a theoretical reference for clinical treatment strategies and drug development for AD, PD, and depression.
在正常生理条件下，肠道微生物群与宿主相互共存。它们在维持肠道屏障完整性、吸收和代谢以及促进中枢神经系统（CNS）发育和情绪调节方面发挥着关键作用。肠道微生物群稳态的失调引起了广泛的研究兴趣，特别是其对神经和精神疾病的影响。最近的研究强调了肠-脑轴在包括阿尔茨海默病（AD）、帕金森病（PD）和抑郁症等疾病中的重要作用。本综述旨在阐明肠道微生物群通过肠-脑轴影响中枢神经系统疾病进展的调节机制。此外，我们讨论了当前的研究现状，找出差距，并提出针对这些疾病的微生物干预的未来方向。最后，我们为AD、PD和抑郁症的临床治疗策略和药物开发提供理论参考。
