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Editorial: Exploring genomic instability of cancers: applications in diagnosis and treatment.

作者信息

Zhang Dong, Lin Shiaw-Yih, Lee Marietta

机构信息

Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, United States.

Center for Cancer Research, New York Institute of Technology, Old Westbury, NY, United States.

出版信息

Front Cell Dev Biol. 2025 Feb 7;13:1528281. doi: 10.3389/fcell.2025.1528281. eCollection 2025.

DOI:10.3389/fcell.2025.1528281
PMID:39989984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11842372/
Abstract
摘要

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本文引用的文献

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Targeting DNA damage response pathways in cancer.靶向癌症中的DNA损伤反应通路。
Nat Rev Cancer. 2023 Feb;23(2):78-94. doi: 10.1038/s41568-022-00535-5. Epub 2022 Dec 5.
2
Targeting the DNA damage response in immuno-oncology: developments and opportunities.靶向免疫肿瘤学中的 DNA 损伤反应：进展与机遇。
Nat Rev Cancer. 2021 Nov;21(11):701-717. doi: 10.1038/s41568-021-00386-6. Epub 2021 Aug 10.
3
Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies.肿瘤缺氧调控免疫逃逸/浸润：对血管生成的影响及缺氧生物标志物对癌症治疗的潜在影响。
Front Immunol. 2021 Jan 20;11:613114. doi: 10.3389/fimmu.2020.613114. eCollection 2020.
4
A guide to cancer immunotherapy: from T cell basic science to clinical practice.癌症免疫疗法指南：从 T 细胞基础科学到临床实践。
Nat Rev Immunol. 2020 Nov;20(11):651-668. doi: 10.1038/s41577-020-0306-5. Epub 2020 May 20.
5
FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.FANCM 通过破坏 TERRA R-环来抑制 ALT 端粒处的 DNA 复制应激。
Sci Rep. 2019 Dec 13;9(1):19110. doi: 10.1038/s41598-019-55537-5.
6
The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT).FANCM-BLM-TOP3A-RMI 复合物抑制端粒的 ALT 延长。
Nat Commun. 2019 May 28;10(1):2252. doi: 10.1038/s41467-019-10180-6.
7
FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops.FANCM 通过限制 BLM 和 R 环引起的端粒复制应激来限制 ALT 活性。
Nat Commun. 2019 May 28;10(1):2253. doi: 10.1038/s41467-019-10179-z.
8
State-of-the-art strategies for targeting the DNA damage response in cancer.针对癌症中 DNA 损伤反应的最新策略。
Nat Rev Clin Oncol. 2019 Feb;16(2):81-104. doi: 10.1038/s41571-018-0114-z.
9
FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.FANCM、BRCA1 和 BLM 协同作用解决 ALT 端粒的复制应激。
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5940-E5949. doi: 10.1073/pnas.1708065114. Epub 2017 Jul 3.
10
Two decades after BRCA: setting paradigms in personalized cancer care and prevention.BRCA 研究二十年：开创个体化癌症治疗与预防的新纪元。
Science. 2014 Mar 28;343(6178):1466-70. doi: 10.1126/science.1251827.