Speck W T, Rosenkranz H S
Environ Mutagen. 1979;1(4):321-36. doi: 10.1002/em.2860010404.
Phototherapy has been shown to be an effective therapy for severe neonatal jaundice. However, because of its seemingly innocuous effect on normal babies, this therapeutic modality has been widely used to prevent jaundice in circumstances where it may be neither necessary nor beneficial. The present report summarizes results which indicate that phototherapy is endowed with DNA-modifying properties and has therefore the potential for inducing genetic and carcinogenic effects. These disconcerting findings concerning the long-term hazardous consequences of an accepted therapeutic procedure require that the unique physiologic and pharmacologic characteristics of the newborn populations be recognized when assessing the risks and benefits of phototherapy.
光疗已被证明是治疗严重新生儿黄疸的有效疗法。然而，由于它对正常婴儿看似无害的影响，这种治疗方式在可能既无必要也无益处的情况下被广泛用于预防黄疸。本报告总结的结果表明，光疗具有DNA修饰特性，因此有可能诱发遗传和致癌效应。这些关于一种公认治疗程序长期有害后果的令人不安的发现要求，在评估光疗的风险和益处时，要认识到新生儿群体独特的生理和药理特征。
