乙醇对大鼠白色脂肪组织中肾上腺素刺激的葡萄糖摄取的影响。

Effect of ethanol on adrenaline-stimulated glucose uptake in rat white adipose tissue.

作者信息

Itaya K

出版信息

J Pharm Pharmacol. 1979 Aug;31(8):536-41. doi: 10.1111/j.2042-7158.1979.tb13579.x.

DOI:10.1111/j.2042-7158.1979.tb13579.x

Abstract

The effect of ethanol on adrenaline-stimulated glucose uptake by rat white adipose tissue has been examined in vitro. Ethanol (3%) inhibited the stimulatory effect of adrenaline on glucose uptake whereas it failed to inhibit the effect of adrenaline on free fatty acid production. Addition of calcium (12.5 mM) to the incubation medium restored adrenaline's effect on glucose uptake. Addition of propranolol also restored the effect of adrenaline inhibited by ethanol. Ethanol did not inhibit insulin-stimulated glucose uptake. These results suggest that ethanol modifies the coupling of the adrenoceptor to the glucose transport system in adipose tissue that is stimulated by adrenaline.

摘要

已在体外研究了乙醇对大鼠白色脂肪组织中肾上腺素刺激的葡萄糖摄取的影响。乙醇（3%）抑制了肾上腺素对葡萄糖摄取的刺激作用，而未能抑制肾上腺素对游离脂肪酸生成的作用。向孵育培养基中添加钙（12.5 mM）可恢复肾上腺素对葡萄糖摄取的作用。添加普萘洛尔也可恢复被乙醇抑制的肾上腺素的作用。乙醇不抑制胰岛素刺激的葡萄糖摄取。这些结果表明，乙醇改变了脂肪组织中肾上腺素刺激的肾上腺素能受体与葡萄糖转运系统之间的偶联。