Ebbing Tobias, Kopp Lena, Frick Konstantin, Simon Tabea, Würtz Berit, Pfannstiel Jens, Schmid-Staiger Ulrike, Bischoff Stephan C, Tovar Günter E M
Fraunhofer Institute for Interfacial Engineering and Biotechnology, 70569 Stuttgart, Germany.
Institute of Interfacial Process Engineering and Plasma Technology (IGVP), University of Stuttgart, Pfaffenwaldring 31, 70569 Stuttgart, Germany.
Mar Drugs. 2025 Jan 26;23(2):58. doi: 10.3390/md23020058.
This study investigates the potential of the diatom (PT) as a sustainable and nutritionally valuable food source, focusing on its ability to produce bioactive compounds such as eicosapentaenoic acid, fucoxanthin, chrysolaminarin (CRY) and proteins. PT was cultivated in a flat-plate airlift photobioreactor (FPA-PBR) illuminated with LEDs from two sides. The study aimed to monitor and minimize β-methylamino-L-alanine (BMAA) levels to address safety concerns. The data showed that the selected FPA-PBR setup was superior in biomass and EPA productivity, and CRY production was reduced. No BMAA was detected in any biomass sample during cultivation. By adjusting the cultivation conditions, PT biomass with different compositional profiles could be produced, enabling various applications in the food and health industries. Biomass from nutrient-repleted conditions is rich in EPA and Fx, with nutritional and health benefits. Biomass from nutrient-depleted conditions accumulated CRY, which can be used as dietary fiber. These results highlight the potential of PT as a versatile ingredient for human consumption and the effectiveness of FPA-PBRs with artificial lighting in producing high-quality biomass. This study also provides the basis for future research to optimize photobioreactor conditions to increase production efficiency and to tailor the biomass profiles of PT for targeted health-promoting applications.
本研究调查了硅藻（PT）作为一种可持续且具有营养价值的食物来源的潜力，重点关注其产生生物活性化合物（如二十碳五烯酸、岩藻黄质、金藻昆布多糖（CRY）和蛋白质）的能力。PT在两侧由发光二极管照明的平板气升式光生物反应器（FPA - PBR）中培养。该研究旨在监测并尽量降低β - 甲基氨基 - L - 丙氨酸（BMAA）水平，以解决安全问题。数据表明，所选的FPA - PBR设置在生物量和EPA生产力方面表现更优，且CRY产量降低。培养过程中在任何生物量样品中均未检测到BMAA。通过调整培养条件，可以生产出具有不同组成特征的PT生物量，从而在食品和健康产业中实现各种应用。营养充足条件下的生物量富含EPA和Fx，具有营养和健康益处。营养耗尽条件下的生物量积累了CRY，可作为膳食纤维使用。这些结果突出了PT作为人类消费通用成分的潜力以及带人工照明的FPA - PBR在生产高质量生物量方面的有效性。本研究还为未来研究提供了基础，以优化光生物反应器条件来提高生产效率，并为促进健康的靶向应用定制PT的生物量特征。
