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海洋真菌生物活性肽的综合评价及其生物学意义

A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt.

Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, North Obhur, P.O. Box 6231, Jeddah 21442, Saudi Arabia.

出版信息

Mar Drugs. 2019 Sep 29;17(10):559. doi: 10.3390/md17100559.

DOI:10.3390/md17100559
PMID:31569458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6835287/
Abstract

Fungal marine microorganisms are a valuable source of bioactive natural products. Fungal secondary metabolites mainly comprise alkaloids, terpenoids, peptides, polyketides, steroids, and lactones. Proteins and peptides from marine fungi show minimal human toxicity and less adverse effects comparable to synthetic drugs. This review summarizes the chemistry and the biological activities of peptides that were isolated and structurally elucidated from marine fungi. Relevant fungal genera including , , , , , , , , , , , , , , , , as well as were extensively reviewed. About 131 peptides were reported from these 17 genera and their structures were unambiguously determined using 1D and 2D NMR (one and two dimensional nuclear magnetic resonance) techniques in addition to HRMS (high resolution mass spectrometry). Marfey and Mosher reactions were used to confirm the identity of these compounds. About 53% of the isolated peptides exhibited cytotoxic, antimicrobial, and antiviral activity, meanwhile, few of them showed antidiabetic, lipid lowering, and anti-inflammatory activity. However 47% of the isolated peptides showed no activity with respect to the examined biological activity and thus required further in depth biological assessment. In conclusion, when searching for bioactive natural products, it is worth exploring more peptides of fungal origin and assessing their biological activities.

摘要

海洋真菌微生物是生物活性天然产物的宝贵来源。真菌次生代谢产物主要包括生物碱、萜类、肽、聚酮、甾体和内酯。与合成药物相比，海洋真菌中的蛋白质和肽的人体毒性极小，不良反应也较少。本综述总结了从海洋真菌中分离和结构鉴定的肽的化学和生物活性。广泛综述了相关的真菌属，包括,,,,,,,,,,,, 以及 。从这 17 个属中报道了约 131 种肽，其结构通过 1D 和 2D NMR（一维和二维核磁共振）技术以及 HRMS（高分辨率质谱）技术得到明确确定。使用 Marfey 和 Mosher 反应来确认这些化合物的身份。约 53%的分离肽具有细胞毒性、抗菌和抗病毒活性，同时，其中一些具有抗糖尿病、降血脂和抗炎活性。然而，约 47%的分离肽在检查的生物活性方面没有活性，因此需要进一步深入的生物学评估。总之，在寻找生物活性天然产物时，值得探索更多真菌来源的肽并评估它们的生物活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/b29a8935256c/marinedrugs-17-00559-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/19d0e0261617/marinedrugs-17-00559-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/00a632ad2087/marinedrugs-17-00559-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/4a31b76d2da6/marinedrugs-17-00559-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/b89cfc8262aa/marinedrugs-17-00559-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/e12ba98ad04f/marinedrugs-17-00559-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/fa2e7f17167e/marinedrugs-17-00559-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/5a768566de43/marinedrugs-17-00559-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/b29a8935256c/marinedrugs-17-00559-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/19d0e0261617/marinedrugs-17-00559-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/00a632ad2087/marinedrugs-17-00559-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/4a31b76d2da6/marinedrugs-17-00559-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/b89cfc8262aa/marinedrugs-17-00559-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/e12ba98ad04f/marinedrugs-17-00559-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/fa2e7f17167e/marinedrugs-17-00559-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/5a768566de43/marinedrugs-17-00559-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a10/6835287/b29a8935256c/marinedrugs-17-00559-g008.jpg

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