Gu Chufan, Jia Hongli, Zhou Kang, Wang Bin, Lin Wenhan, Cheng Wei
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
Ningbo Institute of Marine Medicine, Peking University, Beijing 100191, China.
Mar Drugs. 2025 Jul 30;23(8):312. doi: 10.3390/md23080312.
A chemical investigation of the EtOAc fraction from soft coral resulted in the isolation of 12 undescribed dolabellane-type diterpenoids, namely clavirolides W-Z (-), clavularols A-H (-), and three known analogs (-). Their structures were characterized by an extensive analysis of spectroscopic data, including X-ray diffraction and ECD calculations for the assignment of absolute configurations. The structures of and - are feathered as peroxyl-substituted derivatives, while compounds - possess additional oxidative cyclization, including epoxide or furan that are rare in the dolabellane family. All these compounds were evaluated for activities on cytotoxic and anti-inflammatory models. Compound exhibited most potential against NO production in the BV2 cell induced by LPS with an IC value of 18.3 μM.
对软珊瑚乙酸乙酯馏分进行的化学研究，分离出12种未描述的多拉贝拉烷型二萜类化合物，即克拉维罗内酯W-Z（-）、克拉维罗拉醇A-H（-），以及三种已知类似物（-）。通过对光谱数据进行广泛分析对其结构进行了表征，包括用于确定绝对构型的X射线衍射和电子圆二色性计算。化合物 和 - 的结构为过氧取代衍生物，而化合物 - 具有额外的氧化环化，包括在多拉贝拉烷家族中罕见的环氧化物或呋喃。对所有这些化合物进行了细胞毒性和抗炎模型活性评估。化合物 对脂多糖诱导的BV2细胞中一氧化氮产生表现出最大潜力，IC值为18.3 μM。
