Dolabellane Diterpenoids from Soft Coral with Anti-Inflammatory Activities.

A chemical investigation of the EtOAc fraction from soft coral resulted in the isolation of 12 undescribed dolabellane-type diterpenoids, namely clavirolides W-Z (-), clavularols A-H (-), and three known analogs (-). Their structures were characterized by an extensive analysis of spectroscopic data, including X-ray diffraction and ECD calculations for the assignment of absolute configurations. The structures of and - are feathered as peroxyl-substituted derivatives, while compounds - possess additional oxidative cyclization, including epoxide or furan that are rare in the dolabellane family. All these compounds were evaluated for activities on cytotoxic and anti-inflammatory models. Compound exhibited most potential against NO production in the BV2 cell induced by LPS with an IC value of 18.3 μM.