Alarslan Pinar, Doruk Mehmet
Department of Endocrine and Metabolic Diseases, Istanbul Aydin University, Medical Park Florya Hospital, Besyol, Florya, Akasya Sk., 34295 Kucukcekmece/Istanbul, Turkey.
Department of Endocrine and Metabolic Diseases, İzmir Bozkaya Research and Education Hospital, Bahar, Saim Çıkrıkçı Cd., 35170 Karabağlar/İzmir, Turkey.
J Pers Med. 2025 Feb 15;15(2):70. doi: 10.3390/jpm15020070.
: Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder affecting up to 15% of reproductive-age women, characterized by hyperandrogenism, chronic oligo-ovulation, and metabolic dysfunction. This study aims to evaluate serum sortilin levels in women with PCOS for the first time and investigate their potential associations with metabolic and hormonal alterations. Eighty PCOS patients and 80 healthy controls were included; serum sortilin levels were measured using ELISA kits, with documented intra-assay and inter-assay variations below 6% and 8%, respectively, ensuring high specificity and sensitivity. Serum sortilin levels were significantly elevated in PCOS patients (69.51 ± 27.75 pg/mL) versus controls (48.60 ± 21.20 pg/mL) ( < 0.001). PCOS patients exhibited higher mean HOMA-IR, free androgen index values, serum glucose, insulin, triglycerides, high-sensitivity C-reactive protein, luteinizing hormone, total testosterone, and DHEA-S levels, alongside reduced high-density lipoprotein cholesterol and sex hormone-binding globulin levels (all, < 0.05). Notably, inverse correlations were observed between sortilin and low-density lipoprotein cholesterol levels in both groups ( = 0.028 and 0.033). This pioneering study indicates that serum sortilin may be implicated in PCOS pathogenesis and serves as a potential biomarker for metabolic dysfunction in PCOS. Larger, diverse studies with longitudinal designs are needed for further validation.
多囊卵巢综合征（PCOS）是一种复杂的内分泌紊乱疾病，影响着高达15%的育龄妇女，其特征为高雄激素血症、慢性排卵稀少和代谢功能障碍。本研究旨在首次评估PCOS女性的血清sortilin水平，并调查其与代谢和激素改变的潜在关联。纳入了80例PCOS患者和80例健康对照；使用ELISA试剂盒测量血清sortilin水平，记录的批内和批间变异分别低于6%和8%，确保了高特异性和敏感性。与对照组（48.60±21.20 pg/mL）相比，PCOS患者的血清sortilin水平显著升高（69.51±27.75 pg/mL）（<0.001）。PCOS患者的平均HOMA-IR、游离雄激素指数值、血清葡萄糖、胰岛素、甘油三酯、高敏C反应蛋白、黄体生成素、总睾酮和脱氢表雄酮硫酸盐水平较高，同时高密度脂蛋白胆固醇和性激素结合球蛋白水平降低（均<0.05）。值得注意的是，两组中sortilin与低密度脂蛋白胆固醇水平之间均存在负相关（r=0.028和0.033）。这项开创性研究表明，血清sortilin可能参与PCOS发病机制，并可作为PCOS代谢功能障碍的潜在生物标志物。需要进行更大规模、多样化的纵向设计研究以进一步验证。
