Department of Biomedical Sciences, Dubai Medical College for Girls, Dubai, United Arab Emirates.
Department of Physiology, NUST School of Health Sciences, National University of Sciences and Technology, Islamabad, Pakistan.
Womens Health (Lond). 2024 Jan-Dec;20:17455057241302559. doi: 10.1177/17455057241302559.
Irisin is a myokine potentially linked to insulin sensitivity. Polycystic ovarian syndrome (PCOS) is a prevalent hormonal condition defined by insulin resistance. Previous studies have reported elevated circulating irisin levels in adult females with PCOS.
To examine the differences in serum irisin levels between lean and obese adolescents and young adults with PCOS and their respective lean and obese controls and to explore the relationship between irisin levels and the metabolic and reproductive characteristics of the participants.
Cross-sectional study design.
The study included 60 cases of PCOS and 60 controls. These participants were categorized based on their body mass index (BMI) into lean and obese. Fasting serum irisin levels, physical, metabolic, hormonal, and reproductive characteristics of the participants were measured.
Lean cases of PCOS had significantly elevated levels of fasting serum irisin (PCOS = 17.07 ± 5.61 ng/ml vs lean controls = 11.04 ± 7.51 ng/ml; = 0.002), glucose, insulin, homeostasis model of assessment-insulin resistance index (HOMA-IR), luteinizing hormone (LH), estradiol, and testosterone and significantly lower levels of quantitative insulin sensitivity check index (QUICKI) compared to the lean controls. Obese cases of PCOS had significantly higher levels of fasting serum irisin (PCOS = 22.06 ± 3.83 ng/ml vs obese controls = 16.86 ± 6.74 ng/ml; = 0.011), glucose, insulin, HOMA-IR, LH, estradiol, and testosterone and significantly lower levels of follicle-stimulating hormone (FSH) and QUICKI compared to obese controls. The findings revealed a significant positive correlation of serum irisin levels with BMI, glucose, insulin, HOMA-IR, LH, estradiol, and testosterone(all -values < 0.001). There was also a significant positive correlation with triglycerides (TAGs) ( = 0.001), total cholesterol ( = 0.005), and low-density lipoprotein cholesterol ( = 0.024). Additionally, there was a significant negative correlation with high-density lipoprotein cholesterol ( = 0.001) and QUICKI ( < 0.001) in the entire study cohort. Fasting serum glucose (β = 0.337, = 0.029), TAGs (β = 0.249, = 0.006), and LH (β = 0.382, = 0.004) were positive predictors of serum irisin concentrations in the overall sample.
Lean and obese adolescent and young adult cases of PCOS had significantly higher fasting serum irisin levels than their respective controls. Metabolic and reproductive traits of the participants also correlated with irisin.
鸢尾素是一种与胰岛素敏感性相关的肌肉因子。多囊卵巢综合征（PCOS）是一种以胰岛素抵抗为特征的常见激素紊乱。先前的研究报告称，成年女性 PCOS 患者的循环鸢尾素水平升高。
检查瘦型和肥胖型青少年及年轻成人 PCOS 患者与相应瘦型和肥胖型对照组之间血清鸢尾素水平的差异，并探讨鸢尾素水平与参与者代谢和生殖特征之间的关系。
横断面研究设计。
本研究纳入了 60 例 PCOS 患者和 60 例对照者。根据体重指数（BMI）将这些参与者分为瘦型和肥胖型。测量了参与者的空腹血清鸢尾素水平、身体、代谢、激素和生殖特征。
瘦型 PCOS 患者的空腹血清鸢尾素水平显著升高（PCOS=17.07±5.61ng/ml 比瘦型对照组=11.04±7.51ng/ml；=0.002），血糖、胰岛素、稳态模型评估-胰岛素抵抗指数（HOMA-IR）、黄体生成素（LH）、雌二醇和睾酮水平升高，而定量胰岛素敏感指数（QUICKI）水平降低。肥胖型 PCOS 患者的空腹血清鸢尾素水平显著升高（PCOS=22.06±3.83ng/ml 比肥胖型对照组=16.86±6.74ng/ml；=0.011），血糖、胰岛素、HOMA-IR、LH、雌二醇和睾酮水平升高，而卵泡刺激素（FSH）和 QUICKI 水平降低。研究结果显示，血清鸢尾素水平与 BMI、血糖、胰岛素、HOMA-IR、LH、雌二醇和睾酮呈显著正相关（所有 -值均<0.001）。与甘油三酯（TAGs）（=0.001）、总胆固醇（=0.005）和低密度脂蛋白胆固醇（=0.024）也呈显著正相关。此外，在整个研究队列中，血清鸢尾素水平与高密度脂蛋白胆固醇（=0.001）和 QUICKI（<0.001）呈显著负相关。空腹血糖（β=0.337，=0.029）、TAGs（β=0.249，=0.006）和 LH（β=0.382，=0.004）是总体样本中血清鸢尾素浓度的阳性预测因子。
青少年及年轻成人 PCOS 瘦型和肥胖型患者的空腹血清鸢尾素水平明显高于对照组。参与者的代谢和生殖特征也与鸢尾素相关。
