Contreras-Llanes Manuel, Alguacil Juan, Capelo Rocío, Gómez-Ariza José Luis, García-Pérez Javier, Pérez-Gómez Beatriz, Martin-Olmedo Piedad, Santos-Sánchez Vanessa
Research Group in Clinical, Environmental and Epidemiology Social Transformation (EPICAS), Department of Sociology, Social Work and Public Health, University of Huelva, 21007 Huelva, Spain.
Research Centre for Natural Resources, Health and Environment (RENSMA), Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain.
J Xenobiot. 2025 Feb 8;15(1):29. doi: 10.3390/jox15010029.
Huelva is a city in SW Spain with 150,000 inhabitants, located in the proximity of two heavy chemical industry complexes, the highest naturally occurring radioactive material (NORM) waste (phosphogypsum) stacks of Europe and a highly polluted estuary, with elevated cardiovascular disease and cancer mortality rates. This study analyses the association between cumulated exposure levels to 16 metal(loid)s (Al, As, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Se, Tl, U, V, and Zn) measured in the toenail of a sample ( = 55 participants) of the general control population of Huelva City who were involved in the MCC-Spain study and the spatial proximity patterns to the local polluting sources. Residents of the city of Huelva have higher levels of Fe, Ni, Cr, Se, As, and Co in their toenails compared to the levels found in populations with similar characteristics living in non-polluted areas. Moreover, the highest concentrations of As, Pb, Cd, Mo, and Se were found in toenails of participants living near the NORM waste stack, while the highest Cu, Zn, and Al contents corresponded to people residing near the industrial area. The spatial distribution of most of the metal(loid)s studied appears to be mainly controlled by anthropogenic factors.
韦尔瓦是西班牙西南部一座拥有15万居民的城市，位于两座大型化学工业园区附近，这里有欧洲最大的天然放射性物质（NORM）废料（磷石膏）堆以及一个污染严重的河口，当地心血管疾病和癌症死亡率较高。本研究分析了参与西班牙MCC研究的韦尔瓦市一般对照人群样本（n = 55名参与者）脚趾甲中测量的16种金属（类金属）（铝、砷、镉、钴、铬、铜、铁、锰、钼、镍、铅、硒、铊、铀、钒和锌）的累积暴露水平与当地污染源的空间 proximity模式之间的关联。与生活在无污染地区的具有相似特征人群相比，韦尔瓦市居民脚趾甲中的铁、镍、铬、硒、砷和钴含量更高。此外，在靠近NORM废料堆居住的参与者脚趾甲中发现了最高浓度的砷、铅、镉、钼和硒，而最高的铜、锌和铝含量则对应于居住在工业区附近的人群。所研究的大多数金属（类金属）的空间分布似乎主要受人为因素控制。
