Li Chao, Su Zhaoyin, Deng Shulu, Zhang Binhao, Qin Junlong, Wu Kun, Zhao Yanzong, Liu Yao
Department of Emergency, The Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, China.
The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
PLoS One. 2025 Feb 25;20(2):e0319146. doi: 10.1371/journal.pone.0319146. eCollection 2025.
Traumatic cerebral contusion (CC) is a severe type of injury among traumatic brain injury (TBI) patients. Individuals with traumatic CC typically exhibit rapid deterioration in their condition, leading to increased mortality rates. Despite this, there is a gap in evidence-based research. This study aims to identify the risk factors associated with adverse outcomes in patients with traumatic CC, with a particular focus on relevant biomarkers. Mortality will be the primary outcome, while the Glasgow Coma Scale (GCS) score will be considered as a secondary outcome.
We intend to conduct a comprehensive search through multiple Chinese and English repositories, covering the duration from the establishment of these databases up to the current era, in order to pinpoint appropriate studies. Additionally, a manual search of the references within the included literature and other pertinent works will be undertaken. The primary endpoint of this study will be the survival status of patients with traumatic brain contusion. Meta-analysis will be executed using STATA 16.0 (Stata Corporation, College Station, TX). Article selection and data extraction will be performed independently by two reviewers. The assessment of bias risks will be conducted via the Cochrane Collaboration's tool. Depending on the heterogeneity evaluation, either a fixed-effect model or a random-effects model will be applied. Subgroup and sensitivity analyses will be conducted as needed. The examination of publication bias will be carried out, and the quality of evidence for the primary outcomes will be graded. Trial registration number: CRD42023389456.
创伤性脑挫伤（CC）是创伤性脑损伤（TBI）患者中一种严重的损伤类型。创伤性CC患者通常病情迅速恶化，导致死亡率增加。尽管如此，循证研究仍存在空白。本研究旨在确定创伤性CC患者不良结局的相关危险因素，特别关注相关生物标志物。死亡率将作为主要结局，而格拉斯哥昏迷量表（GCS）评分将被视为次要结局。
我们打算通过多个中英文数据库进行全面检索，涵盖从这些数据库建立到当前时期，以确定合适的研究。此外，将对纳入文献及其他相关著作中的参考文献进行手工检索。本研究的主要终点将是创伤性脑挫伤患者的生存状态。将使用STATA 16.0（Stata公司，德克萨斯州大学城）进行荟萃分析。文章筛选和数据提取将由两名审阅者独立进行。将通过Cochrane协作网的工具进行偏倚风险评估。根据异质性评估结果，将应用固定效应模型或随机效应模型。将根据需要进行亚组分析和敏感性分析。将进行发表偏倚检验，并对主要结局的证据质量进行分级。试验注册号：CRD42023389456。
