Richter W O, Schwandt P
Metabolism. 1985 Jun;34(6):539-43. doi: 10.1016/0026-0495(85)90191-x.
The proopiocorticomelanotropin (POMC) sequence beta-lipotropin stimulates glycerol release from incubated rabbit adipocytes at a minimal concentration of 10(-9) mol/L. However, when lipolysis inhibiting substances (eg, fatty acids and adenosine) and contaminating peptide degrading activity are continuously removed by fat cell perifusion, the sensitivity is increased to 10(-13) and partly to 10(-14) mol/L beta-lipotropin. This higher sensitivity of the perifused adipocyte could also be demonstrated with alpha-MSH (from 5 X 10(-10) to 10(-13) mol/L). The restimulation of glycerol release was shown for both peptides. We conclude that POMC peptides might be involved in the regulation of lipolysis since the minimal effective concentrations are near to plasma concentrations.
促阿片-促皮质-促黑素细胞激素（POMC）序列的β-促脂素以最低浓度10⁻⁹mol/L刺激培养的兔脂肪细胞释放甘油。然而，当通过脂肪细胞灌流持续去除脂解抑制物质（如脂肪酸和腺苷）以及污染的肽降解活性时，敏感性提高到对10⁻¹³mol/L甚至部分对10⁻¹⁴mol/L的β-促脂素。灌流脂肪细胞的这种更高敏感性用α-MSH（从5×10⁻¹⁰到10⁻¹³mol/L）也能证明。两种肽都显示出甘油释放的再刺激。我们得出结论，POMC肽可能参与脂解调节，因为最小有效浓度接近血浆浓度。
