Boosting the X factor: Increasing XBP1s-mediated ER stress signaling protects motor neurons in ALS/FTD.
作者信息
Saxena Smita, Liebscher Sabine
机构信息
Department of Physical Medicine & Rehabilitation, University of Missouri, Columbia, MO, USA; NextGen Precision Health, University of Missouri, Columbia, MO, USA.
Institute of Clinical Neuroimmunology, University Hospital Munich & BioMedical Center, Ludwig Maximilians University Munich, Martinsried, Germany; Institute of Neurobiochemistry, Medical University of Innsbruck, Innsbruck, Austria.
出版信息
Mol Ther. 2025 Mar 5;33(3):844-846. doi: 10.1016/j.ymthe.2025.02.005. Epub 2025 Feb 24.
Abstract
摘要
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本文引用的文献
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Artificial enforcement of the unfolded protein response reduces disease features in multiple preclinical models of ALS/FTD.人工增强未折叠蛋白反应可减轻肌萎缩侧索硬化症/额颞叶痴呆多种临床前模型中的疾病特征。
Mol Ther. 2025 Mar 5;33(3):1226-1245. doi: 10.1016/j.ymthe.2025.01.004. Epub 2025 Jan 10.
2
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer.内质网应激与代谢性疾病、神经退行性疾病和癌症的治疗策略。
Mol Med. 2024 Mar 20;30(1):40. doi: 10.1186/s10020-024-00808-9.
3
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.聚 GA 通过在 C9ORF72-ALS/FTD 的 MAM 上损害 GRP75 的功能来靶向 ER 应激适应性反应。
Acta Neuropathol. 2022 Nov;144(5):939-966. doi: 10.1007/s00401-022-02494-5. Epub 2022 Sep 19.
4
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases.内质网应激与未折叠蛋白反应在心血管疾病中的作用。
Nat Rev Cardiol. 2021 Jul;18(7):499-521. doi: 10.1038/s41569-021-00511-w. Epub 2021 Feb 22.
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ER stress and the unfolded protein response in neurodegeneration.内质网应激与神经变性中的未折叠蛋白反应。
Nat Rev Neurol. 2017 Aug;13(8):477-491. doi: 10.1038/nrneurol.2017.99. Epub 2017 Jul 21.
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A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.自毁性的合成代谢方案通过调节氨基酸通量导致内质网应激诱导的糖尿病中的β细胞凋亡。
J Biol Chem. 2013 Jun 14;288(24):17202-13. doi: 10.1074/jbc.M113.466920. Epub 2013 May 3.
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Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease.Rab6 是未折叠蛋白反应的调节剂：对阿尔茨海默病的影响。
J Alzheimers Dis. 2012;28(4):917-29. doi: 10.3233/JAD-2011-110971.
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