Liao Ying, Tong Xia-Ting, Zhou Ting, Xue Wen-Qiong, Wang Tong-Min, He Yong-Qiao, Zheng Mei-Qi, Jia Yi-Jing, Yang Da-Wei, Wu Yan-Xia, Zheng Xiao-Hui, Zuo Zhi-Xiang, Chen Ming-Yuan, Liu Na, Jia Wei-Hua
State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P.R. China.
School of Public Health, Sun Yat-sen University, Guangzhou 510080, P.R. China.
Cell Rep Med. 2025 Mar 18;6(3):101979. doi: 10.1016/j.xcrm.2025.101979. Epub 2025 Feb 24.
Familial aggregation is common in nasopharyngeal carcinoma (NPC), yet the impact of oral microbiome dysbiosis on this occurrence remains largely unexplored. We recruit 127 families (649 members, 1-5 patients each) and a case-control cohort of 337 individuals, validating findings in an additional cohort of 995 individuals. Significant microbial similarity is observed among family members, with family factors contributing most to microbiome variation, followed by cigarette smoking, age, and gender. Among multi-NPC families, especially those with three or more patients, we identify three NPC-enriched taxa with notable heritability, including Gemella sp. (heritability, h = 53.1%), Lautropia mirabilis (h = 38.8%), and Streptococcus sp. (h = 38.0%). Heritable bacteria present a markedly higher heritability in families with increased clustering of NPC and form closely interacting networks, suggesting their role in NPC familial aggregation. These findings open up possibilities for identifying high-risk individuals, enhancing clinical surveillance, and developing personalized prevention and treatment approaches of NPC through microbiome-based strategies.
家族聚集现象在鼻咽癌（NPC）中很常见，但口腔微生物群失调对其发生的影响在很大程度上仍未得到探索。我们招募了127个家庭（649名成员，每个家庭有1 - 5名患者）以及一个由337名个体组成的病例对照队列，并在另外995名个体的队列中验证了研究结果。在家庭成员之间观察到显著的微生物相似性，其中家庭因素对微生物群变异的贡献最大，其次是吸烟、年龄和性别。在多个鼻咽癌患者的家庭中，尤其是那些有三名或更多患者的家庭，我们鉴定出三种具有显著遗传性的鼻咽癌富集分类群，包括孪生球菌属（遗传性，h = 53.1%）、奇异劳特罗普菌（h = 38.8%）和链球菌属（h = 38.0%）。可遗传细菌在鼻咽癌聚集性增加的家庭中表现出明显更高的遗传性，并形成紧密相互作用的网络，表明它们在鼻咽癌家族聚集中的作用。这些发现为通过基于微生物群的策略识别高危个体、加强临床监测以及制定鼻咽癌的个性化预防和治疗方法开辟了可能性。
