Liu Qiao-Yun, Liao Ying, Wu Yan-Xia, Diao Hua, Du Yan, Chen Yi-Wei, Xie Jin-Ru, Xue Wen-Qiong, He Yong-Qiao, Wang Tong-Min, Zheng Xiao-Hui, Jia Wei-Hua
School of Public Health, Sun Yat-sen University, Guangzhou 510060, China.
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Microorganisms. 2023 Mar 10;11(3):719. doi: 10.3390/microorganisms11030719.
Oral hygiene and the alteration of the oral microbiome have been linked to nasopharyngeal carcinoma (NPC). This study aimed to investigate whether the oral microbiome plays a mediating role in the relationship between oral hygiene and NPC, and identify differential microbial taxonomies that potentially mediated this association. We conducted a case-control study that involved 218 NPC patients and 192 healthy controls. The 16S rRNA gene sequencing of the V4 region was performed to evaluate the composition of the oral microbiome. Mediation analysis was applied to explore the relationship among oral hygiene, the oral microbiome and NPC. We found that dental fillings and poor oral hygiene score were associated with increased risks of NPC (OR = 2.51 (1.52-4.25) and OR = 1.54 (1.02-2.33)). Mediation analysis indicated that dental fillings increased the risk of NPC by altering the abundance of , , and . In addition, also mediated the association between oral hygiene score and the risk of NPC. Our study confirmed that poor oral hygiene increased the risk of NPC, which was partly mediated by the oral microbiome. These findings might help us to understand the potential mechanism of oral hygiene influencing the risk of NPC via the microbiome.
口腔卫生与口腔微生物群的改变已被证明与鼻咽癌（NPC）有关。本研究旨在探讨口腔微生物群在口腔卫生与鼻咽癌关系中是否起中介作用，并确定可能介导这种关联的差异微生物分类群。我们进行了一项病例对照研究，涉及218例鼻咽癌患者和192名健康对照者。通过对V4区域进行16S rRNA基因测序来评估口腔微生物群的组成。采用中介分析来探究口腔卫生、口腔微生物群与鼻咽癌之间的关系。我们发现补牙和不良口腔卫生评分与鼻咽癌风险增加相关（OR = 2.51（1.52 - 4.25）和OR = 1.54（1.02 - 2.33））。中介分析表明，补牙通过改变 、 、 和 的丰度增加了鼻咽癌风险。此外， 也介导了口腔卫生评分与鼻咽癌风险之间的关联。我们的研究证实，不良口腔卫生增加了鼻咽癌风险，部分是由口腔微生物群介导的。这些发现可能有助于我们理解口腔卫生通过微生物群影响鼻咽癌风险的潜在机制。
