Moradi Farhad, Hadi Nahal, Bazargani Abdollah, Abdi Faezeh, Ghorbanian Nastaran
Department of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Bacteriology & Virology, Shiraz University of Medical Sciences, Zand St, Imam Hossein Sq, Shiraz, Iran.
BMC Vet Res. 2025 Feb 26;21(1):107. doi: 10.1186/s12917-024-04431-y.
As recent evidence shows the prevalence and transmission of Aeromonas species in Southwest Asia, and there is no updated information on the characteristics of Aeromonas in Iran, we conducted this review. We systematically searched biomedical databases (PubMed, Web of Sciences, Scopus, SID, ISC, and Google Scholar) to identify relevant studies investigating the prevalence, antibiotic resistance, and main reservoirs of Aeromonas in aquatic animals and human clinical specimens during 2000-2023 in Iran. Cochrane's Q test and I^2 statistical test was used to assess heterogeneity, and publication bias was assessed using funnel plots and random effects tests.
In Iran, among 8347 human clinical samples and 1802 animal and food samples, only 87 (1.04%) and 388 (21.53%) samples were positive for Aeromonas spp. respectively, and the most isolated species was A. hydrophila. The main reservoir for Aeromonas spp. were twenty-four genera of aquatic animals besides minced meat, pigeon stool and chicken meat. In Iran, Aeromonas spp. isolates showed maximum resistance to ampicillin, tetracycline, nalidixic acid and vancomycin. The heterogeneity test for prevalence of Aeromonas species on human samples and animals or food products was significant (88.1256, (5), P-value < 0.0001) and the heterogeneity rate was 97.34% with a confidence interval of 0.2-4.3 and (194.02, (10), P-value < 0.0001) and the heterogeneity rate was 94.85% with a confidence interval of 15,124 - 33,335 respectively.
According to these results, it is essential for exclusive attention to the prevalence and antibiotic resistance of Aeromonas in different provinces of Iran. Furthermore, special planning should be done for prevention, outbreak control and proper treatment of infections in the aquaculture industry and human societies.
由于近期证据显示气单胞菌属在西南亚的流行情况和传播情况，且伊朗缺乏关于气单胞菌特征的最新信息，我们开展了本综述。我们系统检索了生物医学数据库（PubMed、科学网、Scopus、伊朗科学信息数据库、伊朗伊斯兰共和国数据库和谷歌学术），以识别2000年至2023年期间在伊朗调查气单胞菌在水生动物和人类临床标本中的流行情况、抗生素耐药性及主要宿主的相关研究。采用Cochrane's Q检验和I²统计检验评估异质性，并使用漏斗图和随机效应检验评估发表偏倚。
在伊朗，8347份人类临床样本和1802份动物及食品样本中，分别仅有87份（1.04%）和气单胞菌属阳性样本388份（21.53%），分离出最多的菌种是嗜水气单胞菌。气单胞菌属的主要宿主除了碎肉、鸽粪和鸡肉外，还有24属水生动物。在伊朗，气单胞菌属分离株对氨苄西林、四环素酸、萘啶酸和万古霉素表现出最大耐药性。气单胞菌在人类样本以及动物或食品中的流行情况异质性检验具有显著性（88.1256，（5），P值<0.0001），异质性率为97.34%，置信区间为0.2 - 4.3；（194.02，（10），P值<0.0001），异质性率为94.85%，置信区间分别为15124 - 33335。
根据这些结果，必须特别关注伊朗不同省份气单胞菌的流行情况和抗生素耐药性。此外，应制定专门计划，以预防、控制水产养殖业和人类社会中的感染暴发并进行妥善治疗。
