早期生活逆境、炎症与认知之间关联的性别差异。
Sex Differences in the Associations Among Early Life Adversity, Inflammation, and Cognition.
作者信息
Logue Erin, Nemeroff Charles B
机构信息
Department of Psychiatry and Behavioral Sciences, Mulva Clinic for Neurosciences, The University of Texas at Austin Dell Medical School, Austin, TX 78712, USA.
Department of Neurology, Mulva Clinic for Neurosciences, The University of Texas at Austin Dell Medical School, Austin, TX 78712, USA.
出版信息
Biomolecules. 2025 Jan 22;15(2):161. doi: 10.3390/biom15020161.
Early life adversity (ELA) has long been recognized to negatively impact a variety of health outcomes, with increasingly recognized long-term implications for neurocognitive function. ELA may affect the brain through multiple mechanisms, including chronic inflammation. One potential moderator of the pathway from ELA to neuroinflammation to cognitive dysfunction is sex. ELA may leave females potentially even more vulnerable to cognitive impairment in later life. This review discusses the influence of ELA on cognitive function across much of the lifespan, how inflammation is implicated in this process, and the current state of knowledge regarding sex differences in these relationships. We conclude with a discussion of unanswered questions and suggestions for future research, including the incorporation of genetic data.
长期以来，人们一直认为早期生活逆境（ELA）会对多种健康结果产生负面影响，并且越来越认识到其对神经认知功能具有长期影响。ELA可能通过多种机制影响大脑，包括慢性炎症。从ELA到神经炎症再到认知功能障碍这一途径的一个潜在调节因素是性别。ELA可能使女性在晚年更容易受到认知障碍的影响。本综述讨论了ELA在整个生命周期对认知功能的影响、炎症在这一过程中的作用，以及关于这些关系中性别差异的当前知识状态。我们最后讨论了未解决的问题和对未来研究的建议，包括纳入基因数据。
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