Giansanti Daniele
Centro TISP, ISS Via Regina Elena 299, 00161 Rome, Italy.
Biology (Basel). 2025 Jan 28;14(2):134. doi: 10.3390/biology14020134.
Neuroprosthetics for vision restoration have advanced significantly, incorporating technologies like retinal implants, cortical implants, and non-invasive stimulation methods. These advancements hold the potential to tackle major challenges in visual prosthetics, such as enhancing functionality, improving biocompatibility, and enabling real-time object recognition.
The aim of this review overview is to provide a comprehensive analysis of the latest advancements in ocular neuroprostheses.
A narrative review was conducted, focusing on the latest developments in visual neuroprosthetics. Comprehensive searches were carried out on Google Scholar, PubMed, and Scopus using specific keywords. A specific narrative checklist was applied, alongside a tailored quality assessment methodology, to evaluate the quality of the studies included. A total of sixteen relevant studies from the past three years were included in the review.
The integration of artificial retinas, cortical implants, high technology-enabled prosthetics, gene therapies, nanotechnology, and bioprinting has shown significant promise in enhancing the quality and functionality of vision restoration systems, offering potential to address complex visual impairments and improve independence and mobility for individuals with blindness. These innovations appear to have the potential to transform healthcare systems in the future by enabling more efficient and personalized therapies and prosthetic devices. However, challenges such as energy efficiency, scalability, and the neural dynamics of vision restoration persist, requiring continued interdisciplinary collaboration to refine these technologies, overcome ethical and regulatory hurdles, and ensure their effectiveness in real-world applications.
While visual neuroprosthetics have made remarkable progress, addressing challenges related to energy consumption and regulatory and ethical concerns will be crucial for ensuring that neuroprosthetic devices can effectively meet the needs of individuals with visual impairments.
用于视力恢复的神经假体取得了显著进展,融合了视网膜植入物、皮层植入物和非侵入性刺激方法等技术。这些进展有可能应对视觉假体中的重大挑战,如增强功能、提高生物相容性以及实现实时物体识别。
本综述的目的是对眼部神经假体的最新进展进行全面分析。
进行了一项叙述性综述,重点关注视觉神经假体的最新发展。使用特定关键词在谷歌学术、PubMed和Scopus上进行了全面搜索。应用了特定的叙述性清单以及量身定制的质量评估方法来评估纳入研究的质量。本综述共纳入了过去三年的16项相关研究。
人工视网膜、皮层植入物、高科技假肢、基因疗法、纳米技术和生物打印的整合在提高视力恢复系统的质量和功能方面显示出巨大潜力,为解决复杂的视力障碍以及改善盲人的独立性和行动能力提供了可能。这些创新似乎有可能在未来通过实现更高效和个性化的治疗及假肢装置来改变医疗保健系统。然而,诸如能源效率、可扩展性以及视力恢复的神经动力学等挑战依然存在,需要持续的跨学科合作来完善这些技术、克服伦理和监管障碍,并确保它们在实际应用中的有效性。
虽然视觉神经假体已取得显著进展,但应对与能源消耗以及监管和伦理问题相关的挑战对于确保神经假体装置能够有效满足视力障碍患者的需求至关重要。