Xue Lingyan, Huan Yuchen, Chang Yaoguang, Wang Yuming, Tang Qingjuan
College of Food Science and Engineering, Ocean University of China, Qingdao 266400, China.
Foods. 2025 Feb 9;14(4):574. doi: 10.3390/foods14040574.
Fucoidan from (Aj-FUC) is a marine polysaccharide extracted from the high-quality sea cucumber, which has received increasing attention for its multiple biological activities.
In this study, Aj-FUC was extracted, and its basic structure was characterized, while the alleviating efficacy of Aj-FUC on ulcerative colitis (UC) was investigated using C57BL/6 mice. The improvement of Aj-FUC on the fecal gut microbiota in healthy individuals and inflammatory bowel disease (IBD) patients was explored using in vitro simulated fecal fermentation.
The results reflected that Aj-FUC treatment attenuated the histopathological damage associated with colitis, reduced the levels of IL-6, IL-1β, and TNF-α. Aj-FUC treatment also upregulated the expression of ZO-1 and occludin, thereby aiding in the repair of the intestinal barrier. Furthermore, Aj-FUC enhanced the levels of short-chain fatty acids (SCFAs) and helped restore the balance of gut microbiota, particularly by increasing the relative abundance of . In vitro simulation of fecal fermentation showed that Aj-FUC could modulate the gut microbiota of IBD patients and increase the relative abundance of beneficial bacteria.
In conclusion, this study highlights that Aj-FUC can alleviate UC by modulating the levels of inflammatory factors, improving the intestinal barrier, and regulating the intestinal flora in a variety of ways.
来自海参名称未给出的岩藻依聚糖是一种从优质海参中提取的海洋多糖，因其多种生物活性而受到越来越多的关注。
在本研究中，提取了Aj-FUC并对其基本结构进行了表征，同时使用C57BL/6小鼠研究了Aj-FUC对溃疡性结肠炎(UC)的缓解效果。使用体外模拟粪便发酵探索了Aj-FUC对健康个体和炎症性肠病(IBD)患者粪便肠道微生物群的改善作用。
结果表明，Aj-FUC治疗减轻了与结肠炎相关的组织病理学损伤，降低了IL-6、IL-1β和TNF-α的水平。Aj-FUC治疗还上调了ZO-1和闭合蛋白的表达，从而有助于肠道屏障的修复。此外，Aj-FUC提高了短链脂肪酸(SCFAs)的水平，并有助于恢复肠道微生物群的平衡，特别是通过增加[具体细菌名称未给出]的相对丰度。粪便发酵的体外模拟表明，Aj-FUC可以调节IBD患者的肠道微生物群，并增加有益细菌的相对丰度。
总之，本研究强调Aj-FUC可以通过调节炎症因子水平、改善肠道屏障和以多种方式调节肠道菌群来缓解UC。
