出生时豆状核纹状体血管病（LSV）的临床关联：一项病例对照研究。
Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case-Control Study.
作者信息
Kyriakopoulou Aikaterini, Samikos Kyriakos, Kanavaki Aikaterini, Alexopoulou Efthymia, Argyropoulou Maria, Psaltopoulou Theodora, Kanaka-Gantenbein Christina, Dinopoulos Argyrios, Giorgi Melpomene, Antoniadou Anastasia, Filippa Iliani, Siafakas Nikolaos, Serghiou Stylianos, Papaevangelou Vassiliki
机构信息
Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Iaso Maternity Hospital, 151 23 Athens, Greece.
出版信息
Children (Basel). 2025 Feb 12;12(2):223. doi: 10.3390/children12020223.
OBJECTIVE
To investigate the clinical characteristics associated with the presence of LSV at birth.
DESIGN
Prospective 1:1 case-control study.
SETTING
Two tertiary neonatal units in Athens, Greece.
PATIENTS
Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected.
MAIN OUTCOME MEASURE
Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided -values were computed using the likelihood ratio test.
RESULTS
This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV.
CONCLUSIONS
This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV's pathophysiological mechanisms.
目的
研究出生时存在局限性蛛网膜下腔出血（LSV）的临床特征。
设计
前瞻性1:1病例对照研究。
地点
希腊雅典的两个三级新生儿病房。
患者
出生后3周内接受脑部超声检查且检测到LSV的早产新生儿（胎龄≤36周）。
主要观察指标
LSV与出生时临床特征之间的关联。对研究人群按孕周进行了未匹配和匹配分析。使用似然比检验计算双侧P值。
结果
本研究纳入166名参与者（83例病例和83例对照）。患有LSV的新生儿表现出更多并发的脑部检查结果，尤其是脑室周围回声增强。LSV与头围和身长的较高z评分相关。LSV与先天性巨细胞病毒无关。
结论
本研究表明LSV与头围和身长增加之间存在关联。有必要进一步研究以探索LSV的病理生理机制。
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