Cantey Joseph B, Sisman Julide
Department of Pediatrics, Division of NeonatalPerinatal Medicine, University of Texas Southwestern Medical Center, United States; Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, United States.
Department of Pediatrics, Division of NeonatalPerinatal Medicine, University of Texas Southwestern Medical Center, United States.
Early Hum Dev. 2015 Jul;91(7):427-30. doi: 10.1016/j.earlhumdev.2015.04.005. Epub 2015 May 7.
Lenticulostriate vasculopathy (LSV) refers to increased echogenicity of the penetrating vessels that supply the basal ganglia and segments of the internal capsule seen on cranial ultrasound. Initially identified in infants with congenital infection, LSV has now been associated with a variety of infectious and non-infectious conditions. Although robust epidemiologic studies are lacking, the available evidence does not support broad evaluation for multiple congenital infections when LSV is identified. We propose screening infants with LSV for congenital cytomegalovirus infection and ensuring that prenatal screening included appropriate testing for syphilis, human immunodeficiency virus, and rubella-immune status. Large, prospective observational studies are needed to determine the incidence of LSV and the relative contribution of infectious and non-infectious conditions to LSV in the neonate.
豆纹状血管病（LSV）是指在头颅超声检查中，供应基底神经节和内囊节段的穿支血管回声增强。LSV最初在先天性感染的婴儿中被发现，现在已与多种感染性和非感染性疾病相关。尽管缺乏有力的流行病学研究，但现有证据不支持在发现LSV时对多种先天性感染进行广泛评估。我们建议对患有LSV的婴儿进行先天性巨细胞病毒感染筛查，并确保产前筛查包括梅毒、人类免疫缺陷病毒和风疹免疫状态的适当检测。需要进行大规模的前瞻性观察研究，以确定LSV的发病率以及感染性和非感染性疾病对新生儿LSV的相对影响。
