衰老小鼠蓝斑核神经元丢失的定量组织学研究。

A quantitative histological study of neuronal loss from the locus coeruleus of ageing mice.

作者信息

Sturrock R R, Rao K A

出版信息

Neuropathol Appl Neurobiol. 1985 Jan-Feb;11(1):55-60. doi: 10.1111/j.1365-2990.1985.tb00004.x.

DOI:10.1111/j.1365-2990.1985.tb00004.x

Abstract

A quantitative histological study of neurons in the locus coeruleus (LC) was carried out in ASH/TO mice aged 6, 9, 12, 15, 22, 25, 28 and 31 months. Counts were carried out on the right LC in 6 micron parasagittal sections. There was a wide individual variation and also a variation between age groups from 6 and 15 months, but the mean number of neurons in the LC never fell below 1325 until after 25 months. The mean number of neurons in the LC from 6 to 25 months was 1520 +/- 73. The mean number of neurons at 28 and 31 months was 1009 +/- 60 and 854 +/- 146 respectively. This indicates that the pattern of neuron loss in the LC of ASH/TO mice is similar to that found in the normal ageing human brain in a number of quantitative histological studies.

摘要

对6、9、12、15、22、25、28和31月龄的ASH/TO小鼠蓝斑（LC）中的神经元进行了定量组织学研究。在6微米矢状旁切片上对右侧LC进行计数。个体差异很大，6至15月龄的年龄组之间也存在差异，但直到25个月后，LC中神经元的平均数量才降至1325以下。6至25个月时LC中神经元的平均数量为1520±73。28和31个月时神经元的平均数量分别为1009±60和854±146。这表明，在一些定量组织学研究中，ASH/TO小鼠LC中神经元的丢失模式与正常衰老的人类大脑中发现的模式相似。