Han J S, Ding X Z, Fan S G
Neuropeptides. 1985 Feb;5(4-6):399-402. doi: 10.1016/0143-4179(85)90038-1.
Cholecystokinin octapeptide (CCK-8), given intracerebroventricularly (icv) or intrathecally (ith) at the dose range of 0.25-4.0 ng, dose-dependently antagonised the effect of morphine analgesia and electroacupuncture analgesia (EAA) in the rat. That CCK-8 antiserum was capable of reversing the tolerance to EAA and changing the non-responders of EAA into responders suggest CCK-8 to be the endogenous anti-opioid substrate and that blocking the effect of CCK-8 may prove to be a powerful way of augmenting the effect of morphine analgesia and EA analgesia.
脑室内（icv）或鞘内（ith）注射剂量范围为0.25 - 4.0 ng的八肽胆囊收缩素（CCK - 8），可剂量依赖性地拮抗大鼠吗啡镇痛和电针镇痛（EAA）的作用。CCK - 8抗血清能够逆转对EAA的耐受性，并将EAA的无反应者转变为有反应者，这表明CCK - 8是内源性抗阿片类物质底物，阻断CCK - 8的作用可能是增强吗啡镇痛和电针镇痛效果的有效途径。
