一种结合氮化硅和金属化埃洛石纳米管的可拉伸海藻酸钠水凝胶贴片的制备与表征,用于开发慢性伤口愈合治疗方法
Fabrication and Characterization of a Stretchable Sodium Alginate Hydrogel Patch Combined with Silicon Nitride and Metalized Halloysite Nanotubes to Develop a Chronic Wound Healing Treatment.
作者信息
Alakija Femi B, Mills David K
机构信息
Molecular Science and Nanotechnology, Louisiana Tech University, Ruston, LA 71272, USA.
School of Biological Sciences, Louisiana Tech University, Ruston, LA 71272, USA.
出版信息
Int J Mol Sci. 2025 Feb 18;26(4):1734. doi: 10.3390/ijms26041734.
The human body is known as a responsive healing machine, but sometimes, broken bones do not heal, especially if a bacterial infection is present. The present study describes the fabrication and characterization of a nanocomposite hydrogel patch incorporated with silicon nitride and magnesium oxide (MgO) deposited on the halloysite nanotube (HNT) surface using a facile and inexpensive electrodeposition coating process. Scanning electron microscopy (SEM) was used to observe the surface morphology of the MgO/HNT surface coating and the nanocomposite patch. Material characterization, including SEM, contact angle, pore size analysis, and tensile properties, was performed to determine the composite's structure and material properties. and bacterial cultures were used to test the antimicrobial properties. Cellular response to MgO/HNTs was studied using mouse embryonic fibroblasts. The nanocomposite hydrogel patch was discovered to possess inherent properties when tested against bacterial cultures, and it was found to enhance fibroblast cell migration and proliferation. The nanocomposite hydrogel patch also showed sustained drug release. Materials involved in the fabrication helped in the swelling properties by which the nanocomposite hydrogel patch has approximately 400% of its initial weight discovered during the swelling test.
人体被认为是一台有反应的修复机器,但有时,骨折无法愈合,尤其是存在细菌感染的情况下。本研究描述了一种纳米复合水凝胶贴片的制备与表征,该贴片通过简便且低成本的电沉积涂层工艺,将氮化硅和氧化镁(MgO)沉积在埃洛石纳米管(HNT)表面。使用扫描电子显微镜(SEM)观察MgO/HNT表面涂层和纳米复合贴片的表面形态。进行了包括SEM、接触角、孔径分析和拉伸性能在内的材料表征,以确定复合材料的结构和材料性能。并使用细菌培养来测试抗菌性能。使用小鼠胚胎成纤维细胞研究了细胞对MgO/HNTs的反应。在针对细菌培养物进行测试时,发现纳米复合水凝胶贴片具有固有特性,并且发现它能促进成纤维细胞迁移和增殖。纳米复合水凝胶贴片还显示出持续的药物释放。制备过程中涉及的材料有助于其膨胀性能,在膨胀测试中发现纳米复合水凝胶贴片的重量约为其初始重量的400%。