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含蜂胶水凝胶：用于治疗皮肤损伤的物理特性及生物活性评估

Hydrogel Containing Propolis: Physical Characterization and Evaluation of Biological Activities for Potential Use in the Treatment of Skin Lesions.

作者信息

Ferreira Lindalva Maria de Meneses Costa, Cruz Naila Ferreira da, Lynch Desireé Gyles, Costa Patrícia Fagundes da, Salgado Claudio Guedes, Silva-Júnior José Otávio Carréra, Rossi Alessandra, Ribeiro-Costa Roseane Maria

机构信息

Institute of Health Sciences, Federal University of Pará, Belem 66075-110, Brazil.

Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, Brazil.

出版信息

Pharmaceuticals (Basel). 2024 Oct 20;17(10):1400. doi: 10.3390/ph17101400.

DOI:10.3390/ph17101400
PMID:39459039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11510207/
Abstract

BACKGROUND

Skin injury affects the integrity of the skin structure and induces the wound healing process, which is defined by a well-coordinated series of cellular and molecular reactions that aim to recover or replace the injured tissue. Hydrogels are a group of promising biomaterials that are able to incorporate active ingredients for use as dressings. This study aimed to synthesize hydrogels with and without propolis extract and evaluate their physical characteristics and biological activities in vitro for potential use as active dressings in the treatment of skin lesions.

METHODS

The antifungal [ () and ()] and antibacterial [ (), () and ()] activity was assessed by the microdilution method in plates and antioxidant potential by the reduction of the phosphomolybdate complex.

RESULTS

The hydrogels showed good water absorption capacity, high solubility, and high gel fraction, as well as good porosity, water retention, and vapor transmission rates. They revealed a totally amorphous structure. The extract and the hydrogels containing the propolis extract (1.0% and 2.5%) did not inhibit fungal growth. However, they showed antibacterial activity against strains of and . Regarding the strain, only the extract inhibited its growth. It showed good antioxidant activity by the evaluation method used.

CONCLUSIONS

Therefore, the hydrogels containing propolis extract can be a promising alternative with antibacterial and antioxidant action for use as dressings for the treatment of skin lesions.

摘要

背景

皮肤损伤会影响皮肤结构的完整性并引发伤口愈合过程，该过程由一系列协调良好的细胞和分子反应所定义，旨在恢复或替换受损组织。水凝胶是一类有前景的生物材料，能够掺入活性成分用作敷料。本研究旨在合成含和不含蜂胶提取物的水凝胶，并在体外评估它们的物理特性和生物活性，以探讨其作为活性敷料用于治疗皮肤损伤的潜力。

方法

采用平板微量稀释法评估抗真菌活性（白色念珠菌和热带念珠菌）和抗菌活性（金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌），通过磷钼酸盐复合物还原法评估抗氧化潜力。

结果

水凝胶表现出良好的吸水能力、高溶解性和高凝胶分数，以及良好的孔隙率、保水性和透汽率。它们呈现出完全无定形的结构。提取物和含蜂胶提取物（1.0%和2.5%）的水凝胶未抑制真菌生长。然而，它们对金黄色葡萄球菌和大肠杆菌菌株表现出抗菌活性。对于铜绿假单胞菌菌株，只有提取物抑制其生长。通过所使用的评估方法，其显示出良好的抗氧化活性。

结论

因此，含蜂胶提取物的水凝胶作为治疗皮肤损伤的敷料具有抗菌和抗氧化作用，可能是一种有前景的替代品。

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