Cao Huali, Wang Ming, Ding Jianwei, Lin Yiliang
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore.
Department of Dermatology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
J Mater Chem B. 2024 Aug 22;12(33):8007-8032. doi: 10.1039/d4tb00887a.
Inflammatory skin diseases, such as psoriasis and atopic dermatitis, pose significant health challenges due to their long-lasting nature, potential for serious complications, and significant health risks, which requires treatments that are both effective and exhibit minimal side effects. Hydrogels offer an innovative solution due to their biocompatibility, tunability, controlled drug delivery capabilities, enhanced treatment adherence and minimized side effects risk. This review explores the mechanisms that guide the design of hydrogel therapeutic platforms from multiple perspectives, focusing on the components of hydrogels, their adjustable physical and chemical properties, and their interactions with cells and drugs to underscore their clinical potential. We also examine various therapeutic agents for psoriasis and atopic dermatitis that can be integrated into hydrogels, including traditional drugs, novel compounds targeting oxidative stress, small molecule drugs, biologics, and emerging therapies, offering insights into their mechanisms and advantages. Additionally, we review clinical trial data to evaluate the effectiveness and safety of hydrogel-based treatments in managing psoriasis and atopic dermatitis under complex disease conditions. Lastly, we discuss the current challenges and future opportunities for hydrogel therapeutics in treating psoriasis and atopic dermatitis, such as improving skin barrier penetration and developing multifunctional hydrogels, and highlight emerging opportunities to enhance long-term safety and stability.
炎症性皮肤病，如银屑病和特应性皮炎，因其病程持久、有发生严重并发症的可能性以及重大健康风险，对健康构成了重大挑战，这就需要既有效又副作用最小的治疗方法。水凝胶因其生物相容性、可调节性、可控药物递送能力、增强的治疗依从性以及最小化的副作用风险，提供了一种创新解决方案。本综述从多个角度探讨了指导水凝胶治疗平台设计的机制，重点关注水凝胶的成分、其可调节的物理和化学性质，以及它们与细胞和药物的相互作用，以强调其临床潜力。我们还研究了可整合到水凝胶中的用于治疗银屑病和特应性皮炎的各种治疗剂，包括传统药物、针对氧化应激的新型化合物、小分子药物、生物制剂以及新兴疗法，并深入了解它们的作用机制和优势。此外，我们回顾临床试验数据，以评估在复杂疾病情况下基于水凝胶的治疗方法在治疗银屑病和特应性皮炎方面的有效性和安全性。最后，我们讨论了水凝胶疗法在治疗银屑病和特应性皮炎方面当前面临的挑战和未来机遇，例如改善皮肤屏障渗透和开发多功能水凝胶，并强调了增强长期安全性和稳定性的新机遇。
