线粒体底物氧化调节不同的细胞分化结果。
Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes.
作者信息
Park Woo Yong, Montufar Claudia, Zaganjor Elma
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA.
出版信息
Trends Cell Biol. 2025 Apr;35(4):274-277. doi: 10.1016/j.tcb.2025.02.004. Epub 2025 Feb 25.
Abstract
Mitochondrial metabolism, signaling, and dynamics are key regulators of cell fate. While glycolysis supports stemness, mitochondrial expansion and oxidative phosphorylation (OXPHOS) facilitate differentiation. This forum presents emerging evidence that the type of substrate, whether amino acids, carbohydrates, or fatty acids, oxidized by mitochondria significantly influences differentiation outcomes.
摘要
线粒体代谢、信号传导和动力学是细胞命运的关键调节因子。虽然糖酵解支持干性，但线粒体扩张和氧化磷酸化（OXPHOS）促进分化。本论坛展示了新的证据，即线粒体氧化的底物类型，无论是氨基酸、碳水化合物还是脂肪酸，都会显著影响分化结果。
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