代谢调控干细胞生物学的特征。
Metabolic regulation of the hallmarks of stem cell biology.
机构信息
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, New York, NY, USA.
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
出版信息
Cell Stem Cell. 2024 Feb 1;31(2):161-180. doi: 10.1016/j.stem.2024.01.003.
Abstract
Stem cells perform many different functions, each of which requires specific metabolic adaptations. Over the past decades, studies of pluripotent and tissue stem cells have uncovered a range of metabolic preferences and strategies that correlate with or exert control over specific cell states. This review aims to describe the common themes that emerge from the study of stem cell metabolism: (1) metabolic pathways supporting stem cell proliferation, (2) metabolic pathways maintaining stem cell quiescence, (3) metabolic control of cellular stress responses and cell death, (4) metabolic regulation of stem cell identity, and (5) metabolic requirements of the stem cell niche.
摘要
干细胞具有多种不同的功能，每种功能都需要特定的代谢适应。在过去的几十年中，对多能性和组织干细胞的研究揭示了一系列与特定细胞状态相关或对其施加控制的代谢偏好和策略。本综述旨在描述从干细胞代谢研究中得出的一些常见主题：（1）支持干细胞增殖的代谢途径，（2）维持干细胞静止状态的代谢途径，（3）细胞应激反应和细胞死亡的代谢控制，（4）干细胞特性的代谢调节，以及（5）干细胞生态位的代谢需求。
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