Molani-Gol Roghayeh, Rafraf Maryam
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Food Sci Nutr. 2025 May;76(3):226-238. doi: 10.1080/09637486.2025.2466111. Epub 2025 Feb 26.
This systematic review aimed to summarise the current knowledge regarding the effects of the Mediterranean diet (MD) on the secondary prevention of cardiovascular diseases (CVDs). A systematic search was done on Web of Sciences, PubMed, Scopus, and Google Scholar databases until January 2025. The majority of the included studies (15 of 16 RCTs) supported the role of MD following in the secondary prevention of CVDs. According to the RCT results, the patients in the MD group had lower cardiovascular deaths, non-fatal myocardial infarction, and other events. They also had healthier lipid profiles and blood fatty acids, higher flow-mediated dilation and endothelial progenitor cell levels, and lower endothelial progenitor cells compared to a low-fat diet. However, both MD and control (low-fat diet) groups promoted similar decreases in blood pressure and body mass index. The findings of this review suggested that adherence to the MD could be beneficial in the secondary prevention of CVD.
本系统评价旨在总结目前关于地中海饮食（MD）对心血管疾病（CVD）二级预防作用的知识。截至2025年1月，对科学网、PubMed、Scopus和谷歌学术数据库进行了系统检索。纳入的大多数研究（16项随机对照试验中的15项）支持MD在CVD二级预防中的作用。根据随机对照试验结果，MD组患者的心血管死亡、非致命性心肌梗死和其他事件发生率较低。与低脂饮食相比，他们还具有更健康的血脂谱和血液脂肪酸、更高的血流介导的血管舒张和内皮祖细胞水平，以及更低的内皮祖细胞水平。然而，MD组和对照组（低脂饮食）在血压和体重指数下降方面相似。本评价结果表明，坚持MD对CVD的二级预防可能有益。
