Roy Mainak, Dwidmuthe Samir
Department of Orthopaedics, AIIMS Bhubaneswar, Bhubaneswar, India.
Department of Orthopaedics, AIIMS Nagpur, Nagpur, India.
J Med Access. 2025 Feb 24;9:27550834251322005. doi: 10.1177/27550834251322005. eCollection 2025 Jan-Dec.
Brown tumors, though rare, are significant manifestations of hyperparathyroidism, often presenting with multifocal osteolytic lesions and occasionally leading to pathological fractures. This case report details the presentation and management of a 38-year-old male with multifocal brown tumors, including a right tibial fracture, and provides a comprehensive literature review. The patient exhibited multiple osteolytic lesions in the legs, thighs, and forearms, alongside elevated serum calcium and parathyroid hormone (PTH) levels. Management included conservative fracture treatment, surgical resection of the parathyroid adenoma, and postoperative rehabilitation. Follow-up revealed significant tibial fracture healing and reduction in the size of osteolytic lesions. This report underscores the importance of timely diagnosis and comprehensive management to prevent complications and improve outcomes in patients with multifocal brown tumors.
棕色瘤虽罕见,但却是甲状旁腺功能亢进的重要表现,常表现为多灶性溶骨性病变,偶尔会导致病理性骨折。本病例报告详细介绍了一名38岁患有多灶性棕色瘤(包括右胫骨骨折)男性的临床表现及治疗过程,并提供了全面的文献综述。该患者在腿部、大腿和前臂出现多处溶骨性病变,同时血清钙和甲状旁腺激素(PTH)水平升高。治疗措施包括骨折保守治疗、甲状旁腺腺瘤手术切除及术后康复。随访显示胫骨骨折明显愈合,溶骨性病变大小缩小。本报告强调了及时诊断和综合治疗对于预防多灶性棕色瘤患者并发症及改善预后的重要性。